Brachypodium distachyon (Brachypodium) is now intensively utilized as a model grass species in various biological studies. Its favorable cytological features create a unique foundation for a convenient system in mutagenesis, thereby potentially enabling the 'hot spots' and 'cold spots' of DNA damage in its genome to be analyzed. The aim of this study was to analyze the involvement of 5S rDNA, 2...

OBJECTIVES The aim of this study was to investigate the genotoxic effects of indium trichloride (InCl(3)·4H(2)O; InCl(3)) using the in vivo bone marrow micronucleus test and the in vitro CHL/IU cell micronucleus test. METHOD BALB/c mice were administered a single intraperitoneal (i.p.) injection of InCl (3) at a dose 0.625, 1.25, 2.5, 5, or 10 mg/kg b.w. The frequency of micronuclei, the rati...

Ionizing radiation (IR) is known to induce genotoxic damage to DNA, chromosomes, and the nucleus. However, the damage that IR causes to the nucleus has received much less attention. Given that reactive oxygen species (ROS) are involved in IR-induced DNA breaks and chromosomal aberrations, this study examined the role of ROS in IR-induced damage to the nucleus. Human Jurkat T cells were irradiat...

background: previous investigations have revealed, cimetidine, a histamine h2-receptor antagonist, show radioprotective effects against gamma- and neutron-induced micronuclei in bone marrow erythrocytes. in this study, the anticlastogenic effects of famotidine and ranitidine, which act similar to cimetidine as histamine h2-receptor antagonists, was investigated. materials and methods : balb/c m...

THE dimorphic condition of the nuclear apparatus of the Infusoria is one of the most interesting and characteristic specializations exhibited by the group, apparently representing a segregation of ' somatic' and ' germinal' elements into distinct macronuclei and micronuclei. Accordingly these bodies have been extensively studied during the various life-processes of the Infusoria. Furthermore, s...