The objective of the study is to prepare, characterize and evaluate starch phosphate, a new modified starch as a carrier in solid dispersions for enhancing the dissolution rate of ritonavir. The feasibility of formulating solid dispersions of ritonavir in starch phosphate into compressed tablets with enhanced dissolution rate was also investigated. Starch phosphate was prepared by reacting star...

Solid dispersions is an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly soluble drugs. This article reviews the various types of solid dispersion, preparation techniques for solid dispersion and compiles some of the recent technologies. Some of the practical aspects to be considered for the preparation of solid dispersions, such as selection ...

Supercritical Anti-Solvent (SAS) process is considered as a clean technology suitable for particle design, micron or nanometer sized. It is generally used to micronize compounds of interest in mild operating conditions of temperature and nearly without any residual solvent traces in the end-product. By varying the process parameters, the properties of the produced powders can be adjusted with a...

Solid dispersions have been employed to enhance the dissolution rates of poorly water-soluble drugs. Many approaches have been investigated for the preparation of solid dispersions. This paper reports the various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, e...

*To whom all correspondence should be addressed. he quality of a solid pharmaceutical preparation is influenced by primary micromeritic characteristics such as the shape and size of drug crystals, especially when large amounts of poorly soluble drugs are formulated. To improve the dissolution rate of poorly soluble drugs, fine crystals are preferred over large crystals because they provide a gr...

INTRODUCTION Molecular Imaging of transplanted stem and progenitor cells is essential to understand their therapeutic potential. Stable labeling of cells with either iron oxide particles (USPIO) or lanthanide chelates has proven successful for MRI-based detection of cell deposits and their migration [1, 2]. However, MRI only provides information about the location but not about cellular change ...

TOPIC: Pulmonary Vascular Disease TYPE: Original Investigations PURPOSE: To study (i) the pharmacokinetics (PK) and pharmacodynamics (PD) of Zamicastat its main metabolites (ii) intrinsic extrinsic effects on PK PD profiles. METHODS: Data pooled from six phase-I clinical studies in healthy volunteers (N=366) ≥18 years old both genders were integrated, where oral doses ranging 5 to 2400 mg 1200 ...

Lysozyme, as a model protein, was precipitated through the formation of protein-Zn complex to micronize for subsequent encapsulation within poly (lactic-co-glycolic acid) (PLGA) microspheres. Various parameters, including pH, type and concentration of added salts and protein concentration, were modified to optimize the yield of protein complexation and precipitation. The resulting protein parti...

Lysozyme, as a model protein, was precipitated through the formation of protein-Zn complex to micronize for subsequent encapsulation within poly (lactic-co-glycolic acid) (PLGA) microspheres. Various parameters, including pH, type and concentration of added salts and protein concentration, were modified to optimize the yield of protein complexation and precipitation. The resulting protein parti...