OBJECTIVES Alginate, known as a group of anionic polysaccharides extracted from seaweeds, has attracted the attention of researchers because of its biocompatibility and degradability properties. Alginate has shown beneficial effects on wound healing as it has similar function as extracellular matrix. Alginate microcapsules (AM) that are used in tissue engineering as well as Dulbecco's modified E...

Consistent liver metastases in animal models is generally observed only with certain cancer cell lines. With the aim of improving on existing animal models of liver metastases, we hypothesized that cancer cells encased in 300 microm microcapsules, mimicking micrometastatic foci, might be effective seeds of liver metastases. A total of 3,000 microcapsules, containing 700 to 1,500 viable cells/ca...

The main goal of this research was to compare the in vitro release rates of nano- and microcapsules of Silybum marianum extract (SME) in animal simulated gastric and intestinal medium conditions. The extract was encapsulated within sodium alginate carriers using emulsification/internal gelation method. Particle size, zeta potential, polydispersity index (PDI) and morphology of...

We present the layer-by-layer (LbL) assembly of amphiphilic heteroarm pH-sensitive star-shaped polystyrene-poly(2pyridine) (PSnP2VPn) block copolymers to fabricate porous and multicompartmental microcapsules. Pyridine-containing star molecules forming a hydrophobic core/hydrophilic corona unimolecular micelle in acidic solution (pH 3) were alternately deposited with oppositely charged linear su...

Uniform-sized biodegradable PLA/PLGA microcapsules loading recombinant human insulin (rhI) were successfully prepared by combining a Shirasu Porous Glass (SPG) membrane emulsification technique and a double emulsion-evaporation method. An aqueous phase containing rhI was used as the inner water phase (w1), and PLA/PLGA and Arlacel 83 were dissolved in a mixture solvent of dichloromethane (DCM) ...

Microcapsules offer a wide variety of convenience in drug delivery when compared with conventional dosage forms. It is unique carrier system for many pharmaceuticals. Microencapsulation potential process which prolongs the efficacy significantly and improves patient compliance. This approach can alleviate limitations dose dumping, multiple inconvenience, kidney disease. form has advantages elde...

Self-healing epoxy waterborne polyurethane (EWPU) was prepared by embedding mercaptan-contained microcapsules. Once microcracks expanded, microcapsules ruptured and mercaptan released to the valley of microcrack realize self-healing.

microparticles offer various significant advantages as drug delivery systems, including: (i) an effective protection of the encapsulated active agent against (e.g. enzymatic) degradation, (ii) the possibility to accurately control the release rate of the incorporated drug over periods of hours to months, (iii) an easy administration (compared to alternative parenteral controlled release dosage ...

The effect of wax-containing microcapsules incorporated in silicone composite coatings deposited on aluminum (Al) alloy substrates on the tribological performance of the coatings was systematically investigated. The wax-containing microcapsules were prepared via in situ polymerization. The tribological behavior of the composite coatings was evaluated using ball-on-disk tribological test. It was...

Essential oils have important commercial applications as preservatives and flavours, and more recently as natural antimicrobial agents. These applications require a suitable formulation constituted by biodegradable compounds that protect the essential oil from degradation and evaporation at the same time that allows for a sustained release. Microcapsules of biopolymers loaded with essential oil...