Abstract Background High-fat diet (HFD) is closely related to the occurrence and development of IBD, which increases level deoxycholic acid (DCA). DCA-treated mice showed pro-inflammatory cell infiltration colonic inflammation. Ferroptosis, a newly recognized form death characterized by iron overload generation reactive oxygen species (ROS) has recently been observed in colitis. Whether DCA aff...

A new antibiotic, named seitomycin (1c), and the known microbial metabolite tetrangulol methyl ether (2) were found in the ethyl acetate extract of two terrestrial Streptomyces sp. isolates. The structure of the new antibiotic was elucidated by spectroscopic studies and by comparison of the NMR data with the structurally related hatomarubigin C (1a) and SM-196 B (1b). Seitomycin (1c) showed mod...

Soil microbial communities are responsible for a wide range of ecological processes and have an important economic impact in agriculture. Determining the metabolic processes performed by microbial communities is crucial for understanding and managing ecosystem properties. Metagenomic approaches allow the elucidation of the main metabolic processes that determine the performance of microbial com...

this study was performed to determine the effect of copper on growth performance, blood metabolites and claw health in young holstein bulls in a humid area in north of iran. one hundred and two young holstein bulls (initial body weight= 377.3±17.1 kg) were randomly allocated to two treatments in a completely randomized design for 56 days. the treatment groups received: (1) the basal diet of no ...

N-Hydroxy-desferrioxamine B (5), a postulated metabolite of the microbial product desferrioxamine B (1), has been prepared by reduction of the intermediate oxime 6 with sodium cyanoborohydride. The oxime was obtained by selective oxidation of desferrioxamine B with hydrogen peroxide and a catalytic amount of sodium tungstate dihydrate. The iron complex derived from 5 enabled definite proof of t...

Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides n...