BACKGROUND Antibody-based therapeutics is a rapidly growing field. Small engineered antibody fragments demonstrate similar antigen affinity compared with the parental antibody but have a shorter serum half-life and possess the ability to be conjugated to nanoparticles. The goal of this study was to engineer an anti-carbohydrate antigen 19-9 (CA19-9) cys-diabody fragment in hopes of targeting na...

In this paper, we provide a novel micro rectangular-shaped long-period fiber grating (MRSLPFG) coated with Fe₃O₄ nanoparticles as the sensing material and packaged in polydimethylsiloxane (PDMS) for magnetic sensing application. The micro rectangular-shaped grating structures are fully dip coated with the magnetic fluid and heated to form a thin solid film. This thin overlay is used as the sens...

Strategies that target and treat biofilms are widely applied to bacterial cultures using popular live/dead staining techniques with mostly red or green fluorescent markers (eg, with SYTO(®) 9, propidium iodide, fluorescein). Therefore, visualizing drugs or micro- and nanoparticulate delivery systems to analyze their distribution and effects in biofilms requires a third fluorescent dye that does...

Directing neuronal migration and growth has an important impact on potential post traumatic therapies. Magnetic manipulation is an advantageous method for remotely guiding cells. In the present study, we have generated highly localized magnetic fields with controllable magnetic flux densities to manipulate neuron-like cell migration and organization at the microscale level. We designed and fabr...

Soft-bodied magnetically actuated microrobots could be developed by including controlled dispersions of magnetic nanoparticles into polymeric micro-fabricated structures. The characterization and actuation of magnetically active soft-bodied microrobots by tailored magnetic fields is, thus, a key issue for the design, full control and further development of these mobile micro-systems. In this wo...

Development of micro- and nanotechnology for the study of living cells, especially in the field of drug delivery, has gained interest in recent years. Although several studies have reported successful results in the internalization of micro- and nanoparticles in phagocytic cells, when nonphagocytic cells are used, the low internalization efficiency represents a limitation that needs to be overc...

Endostar, a novel recombinant human endostatin, which was approved by the Chinese State Food and Drug Administration in 2005, has a broad spectrum of activity against solid tumors. In this study, we aimed to determine whether the anticancer effect of Endostar is increased by using a nanocarrier system. It is expected that the prolonged circulation of endostar will improve its anticancer activit...

J. L. Gao, Y. Zhi, X. F. Ren, Y. H. Liu, College of Material Science and Engineering, Shenyang Ligong University, Shenyang, Liaoning, China. Barium titanate (B aTiO3) nanoparticles were successfully synthesized by using a surfactant-assisted method. The various processing parameters, namely, th e species of surfactant, reaction temperature and micro-emusion concentration had been varied, and th...

Nanoparticles of tin oxide, doped with Ce and Y, were prepared using the polymeric precursor method. The structural variations of the tin oxide nanoparticles were characterized by means of nitrogen physisorption, carbon dioxide chemisorption, X-ray diffraction, and X-ray photoelectron spectroscopy. The synthesized samples, undoped and doped with the rare earths, were used to promote the ethanol...