1 Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK 2 Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK 3 IfADo – Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany 4 Friedrich-Baur Institute, Ludwig Maximilian University, Munich, Germany ...

Glycoprotein 78 (Gp78) is a critical E3 ubiquitin ligase in endoplasmic reticulum-associated degradation. Overexpression of Flag-tagged Gp78 (Flag-gp78), but not Flag-gp78 mutated in its RING-finger domain (Flag-RINGmut) with deficient ubiquitin ligase activity, induces mitochondrial fragmentation and ubiquitination and proteasome-dependent degradation of the mitofusin (Mfn) mitochondrial fusio...

BACKGROUND Anesthetic postconditioning is a cellular protective approach whereby exposure to a volatile anesthetic renders a tissue more resistant to subsequent ischemic/reperfusion event. Sevoflurane postconditioning (SPostC) has been shown to exert cardioprotection against ischemia/reperfusion injury, but the underlying mechanism is unclear. We hypothesized that SPostC protects cardiomyocytes...

Hydin fl ips flagella H ydin is hiding no longer. On page 473, Lechtreck and Witman locate this protein to the buried central pair (CP) of fl agellar microtubules. The paralysis of cilia lacking hydin might be a basis for hydrocephalus-inducing brain fl uid accumulation. Flagella contain lots of hydin, but no one had yet localized the protein in any system. Lechtreck and Witman have now spotted...

BackgroundEmerging evidence points to a central role of mitochondria in psychiatric disorders. However, little is known about the molecular players that regulate neural circuits regulating anxiety and depression how they impact neuronal structure function. Here, we investigated molecules involved mitochondrial dynamics medium spiny neurons (MSNs) from nucleus accumbens (NAc), hub brain’s motiva...