Objective(s):Rapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. The purpose of the present study was to examine the effect of rapamycin on testicular ischemia-reperfusion injury. Materials and Methods: Seventy-two adult male Wistar rats w...

A randomised double-blind crossover study was undertaken to compare the anti-emetic efficacy of alizapride against high dose metoclopramide. A total of 32 patients on cisplatin were randomised to receive either high dose metoclopramide (7 mg kg-1 day-1) or alizapride (5 mg kg-1 day-1). Anti-emetic responses in terms of control of vomiting episodes were similar in both regimens (59%). However, p...

and commentary also appear in ACP Journal Club. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . For correspondence: Dr B H Rowe, University of Alberta, Calgary, Alberta, Canada. [email protected] Source of Funding: Canadian Institute of Health Research and Canadian Association of Emergency Physicians Research Consort...

3 McCallum RW, Kline MM, Curry N, Sturdevant RAL. Comparative efforts of metoclopramide and bethanechol on lower esophageal sphincter pressure in reflux patients. Gastroenterology 1975;68:1 114-8. McCallum RW, Berkowitz DM. The frequency of delayed gastric emptying in patients with gastroesophageal reflux and its response to metoclopramide and bethanechol. Gastroenterology 1978 ;74:1135. Gugler...

OBJECTIVE To compare the effects of promethazine with those of metoclopramide for hyperemesis gravidarum. METHODS Women at their first hospitalization for hyperemesis gravidarum were approached when intravenous antiemetic therapy was needed. They were randomly assigned to receive 25 mg promethazine or 10 mg metoclopramide every 8 hours for 24 hours in a double-blind study. Primary outcomes we...

To investigate the possible long-term consequences of gestational exposure to cannabinoids on cognitive functions, pregnant rats were administered with the CB1 receptor agonist WIN 55,212-2 (WIN), at a dose (0.5 mgkg) that causes neither malformations nor overt signs of toxicity. Prenatal WIN exposure induced a disruption of memory retention in 40- and 80-day-old offspring subjected to a passiv...

A study was conducted in the alluvial soils located in Oko-anala in Delta State, Nigeria. These alluvial soils are primarily used for intensive vegetable production for commercial purposes. The total land area of about 3.34 Square kilometer was divided into three consociations and composite soil samples collected from pre-determined depths of 0-15 and 16-30cm. The samples were routinely prepare...

Experiments using electrical stimulation of different groups of muscle afferent nerve fibres have shown that most of the known medullated fibres in muscle nerves are involved in reflexly stimulatihg ventilation (Bessou et al. 1959, Koizumi et al. 1961, Senapati 1966). Investigations using natural stimulation of muscle receptors and pmsive limb movements (Kao et al. 1963, Senapati 1966, Kalia et...

BACKGROUND A growing body of evidence suggests that some cardiovascular drugs could modulate the level of proinflammatory cytokines. Therefore, the aim of the present study was to investigate whether celiprolol, a third generation β-adrenoceptor blocker, affects lipopolysaccharide (LPS)-induced serum concentrations of TNF-α, IL-1β, IL-6 in normotensive (WKY) and spontaneously hypertensive (SHR)...