Coronary artery disease is the leading cause of mortality and morbidity in the world. Left main coronary artery disease (LMCAD) is a particularly severe phenotypic form of CAD and has a genetic basis. We hypothesized that some inflammation- and hyperhomocysteinemia-related gene polymorphisms may contribute to LMCAD susceptibility in a Chinese population. We studied the association between polym...

In colorectal cancer chemotherapy, the current standard of care includes combination therapy with 5-fluorouracil (5-FU) and leucovorin (LV). However, the factors that determine the LV-mediated enhancement of 5-FU antitumor activity are not fully understood. Therefore, we investigated the roles of thymidine synthase (TYMS), folate receptor 1 (FOLR1), dihydrofolate reductase (DHFR), phosphoribosy...

Rapidly proliferating tumors attempt to meet the demands for nucleotide biosynthesis by upregulating folate pathways that provide the building blocks for pyrimidine and purine biosynthesis. In particular, the key role of mitochondrial folate enzymes in providing formate for de novo purine synthesis and for providing the one-carbon moiety for thymidylate synthesis has been recognized in recent s...

Women who take folic acid periconceptionally reduce their risk of having a child with a neural tube defect (NTD) by >50%. A variant form of methylenetetrahydrofolate reductase (MTHFR) (677C-->T) is a known risk factor for NTDs, but the prevalence of the risk genotype explains only a small portion of the protective effect of folic acid. This has prompted the search for additional NTD-associated ...

BACKGROUND Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have recently raised the interest as a possible thrombophilic factors. AIMS We aimed to assess the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in idiopathic venous thromboembolism (VTE) in a Romanian population and the associated risk of VTE. STUDY DESIGN We performed a case-...

Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in the females worldwide, accounting for 9% (529,800 cases) of the total new cancer cases and 8% (275,100 deaths) of the total cancer deaths among females in 2008 (Jemal et al., 2011). More than 85% of these cases and deaths occur in developing countries (Jemal et al., 2011, Li et al., 2011)...

Objective Synthetic folic acid is widely used, amongst others in the prevention of neural tube defects and reducing homocysteine, a risk factor for cardiovascular disease. Its effect on intracellular folate and the activity of essential cellular folate-converting enzymes is poorly understood. Methods Six lymphoblast cell lines were cultured for 15 days with medium containing either FA, 5-methyl...

Thromboembolism is a clinical finding that occurs due to thrombus; formed in the vascular system and has various etiological factors. It can be classified as central peripheral thromboembolism. Our objective this study explore genetic risk factors thromboembolism reveal differences. 342 patients were retrospectively included between January 2016 December 2019. Demographic characteristics, for m...

Female athletes who endure physical strain on the same bone area are prone to stress fractures. Preventing these improves their quality of life. Blood vitamin B2 (V.B2) and E (V.E) levels influence blood homocysteine (Hcy) levels, which, when elevated, increase risk We aimed determine effects V.B2 V.E supplementation plasma Hcy concentrations in carrying C677T polymorphism methylenetetrahydrofo...