In recent years, the use of genome-wide technologies has revolutionized the study of eukaryotic transcription producing results for thousands of genes at every step of mRNA life. The statistical analyses of the results for a single condition, different conditions, different transcription stages, or even between different techniques, is outlining a totally new landscape of the eukaryotic transcr...

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Based on the above mechanisms of mRNA degradation, an integrated model of mRNA turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be degraded by the deadenylation-dependent pathway at some rate. In addition to this default pathway, another layer of complexity would come from degradation mechanisms specific to individual mRNAs or to classes of mRNAs. Such mRNA-spe...

The selective autophagy receptors Atg19 and Atg32 interact with two proteins of the core autophagic machinery: the scaffold protein Atg11 and the ubiquitin-like protein Atg8. We found that the Pichia pastoris pexophagy receptor, Atg30, also interacts with Atg8. Both Atg30 and Atg32 interactions are regulated by phosphorylation close to Atg8-interaction motifs. Extending this finding to Saccharo...

Proper protein turnover is required for cardiac homeostasis and, accordingly, impaired proteasomal function appears to contribute to heart disease. Specific proteasomal degradation mechanisms underlying cardiovascular biology and disease have been identified, and such cellular pathways have been proposed to be targets of clinical relevance. This review summarizes the latest literature regarding...

this research was performed to compare electron beam (eb) and gamma ray (gr) treatments at doses of 25, 50 and 75 kilo gray (kgy) on ruminal degradation kinetics and in vitro digestibility of sunflower meal (sfm). ionizing radiations of eb and gr had significant effects )p

the effects of pre-treating different types of roughages with alkali on the efficacy of exogenous fibrolytic enzymes for improving their digestibility were studied in vitroin factorial arrangement 4 × 3 × 5 (enzyme, treatment and roughage types). two fibrolytic feed enzymes novozyme (n) and celloclast (c) their combination (n+c) were evaluated for their potential to improve in vitrodegradation ...

the solutions of mathematical models for the estimation of the kinetic, and biokinetic parameters of naphthalene, anthracene and pyrene during degradation in surface and subsurface soils are presented in this work. the models were developed using the twin concepts of rate-determining step and steady-state approximation method. they described the biodegradation of single and a mixture of polycy...

thermoplastic polyurethane (tpu)/clay nanocomposites were prepared via a melt-compounding method using ester type tpu and two different modified organoclays (cloisite 30b and cloisite 15a) in different contents. the effects of the chemical structure and content of the nanoclays on the thermal degradation and mechanical properties of tpu were also investigated. the effect of structural modificat...