tigecycline is a new glycylcycline antibiotic structurally similar to minocycline antibiotic. it has broad spectrum activity, including staphylococcus aureus infections. this is the first study that evaluated the activity of tigecycline against staphylococcus aureus isolated from biological samples in iran. in vitro activity of tigecycline against 160 staphylococcus aureus including 99 methicil...

background and objectives: staphylococcus aureus is a versatile organism causing mild to life threatening infections. the major threat of this organism is its multidrug resistance. the present study was carried out to investigate in - vitro activity of conventional antibiotics routinely prescribed for methicillin resistant s. aureus (mrsa) and methicillin sensitive s. aureus (mssa) infections i...

Methicillin (intrinsic) resistance of Staphylococcus aureus was suppressed almost completely by regulatory gene (penI(1)) mutations of penicillinase plasmids that made penicillinase production strictly noninducible. Methicillin resistance was restored by secondary regulatory gene mutations that altered the noninducible phenotype or by complementation with a compatible plasmid that did not bear ...

The MRSA screen test (Denka Seiken Co., Ltd.), a commercially available, rapid (20-min) slide latex agglutination test for the determination of methicillin resistance by detection of PBP 2a in Staphylococcus aureus, was compared with the oxacillin agar screen test and PCR detection of the mecA gene. A total of 563 S. aureus isolates were tested. Two hundred ninety-six of the isolates were methi...

Background: Methicillin Resistant Staphylococcus aureus (MRSA) is a variant of Staphylococcus aureus which is resistant to all ß-lactams. Infections due to (MRSA) strains have been detected worldwide and it makes the treatment of common infections much more difficult. Objectives: This study was carried out to determine and compare the Antibiotic susceptibility patterns in Methicillin Resistant ...

conclusions these findings showed no significant difference regarding the presence of icaadbc genes between blood and wound isolates. background the polysaccharide intercellular adhesion (pia) produced by staphylococcus aureus is effective in the protection of isolates from outer harsh conditions and progress of infection. objectives the aim of this study was to compare the icaabcd genes encodi...

introduction: in this study, using the phenotypic and genotypic methods, oxacillin susceptibility in staphylococcus aureus (s. aureus) strains isolated from patients at two government hospitals in ilam, iran was tested. materials and methods: out of 200 s. aureus isolates from different human clinical specimens consisting of blood (31%), wound (20%), urine (21%), catheters (7%), sputum (12%), o...

The aim of the present study was to estimate the impact of methicillin resistance on mortality in ventilator-associated pneumonia (VAP) due to Staphylococcus aureus. PubMed, Scopus and the bibliographies of the eligible studies were searched. The DerSimonian-Laird random effects model was used to determine the effect of methicillin resistance on mortality. Eight articles were included. Crude in...

background and objectives: methicillin-resistant staphylococcus aureus (mrsa) is a major cause of nosocomial and community acquired infections. detection of mrsa in laboratories is very important for treatment and appropriate infection control. the aim of this study was to evaluate cefoxitin disk diffusion method for detection of mrsa and comparison of this method with other conventional method...

backgroundandobjectives:rapidandaccuratedetectionofmethicillinresistantstaphylococcus aureus (mrsa) is an important role of clinical microbiology laboratories to avoid treatment failure. the aim of this study was to compare conventional methods against the e-test minimum inhibitory concentration (mic) method to determine the best phenotypic method. materials and methods: methicillin resistance...