The synthesis of a ruthenium complex containing an N-heterocylic carbene (NHC) and a mesoionic carbene (MIC) is described wherein addition of a Brønsted acid results in protonolysis of the Ru-MIC bond to generate an extremely active metathesis catalyst. Mechanistic studies implicated a rate-determining protonation step in the generation of the metathesis-active species. The activity of the NHC/...

The addition of allyl magnesium and allyl indium reagents to a key TBS protected norbornenyl building block, synthesised in 6-steps from commercially available 1,1-dimethoxy-2,3,4,5-tetrachlorocyclopentadiene, has been achieved providing the syn addition products with high diastereoselectivity. The subsequent exposure of the addition products to metathesis conditions, in the presence of ethene,...

Fluorescent, aqueous-soluble, crosslinked dendronized polyols (CDPs) are obtained through a sequential process involving ring-opening metathesis polymerization (ROMP), intra-chain ring-closing metathesis (RCM), and hydrolysis. This general strategy improves the quantum yields (QYs), brightness, and photostability of five common fluorophores whose emission wavelengths cover 150 nm. Additionally,...

Alkyne metathesis (AM), the cousin of ‘noble' alkene metathesis, has attracted rapidly growing attention within past 20 years and been widely used in synthesis natural products, functional polymers, shape-persistent molecular architectures. Given some excellent reviews recent years, this article will not provide a comprehensive review catalyst development wide applications AM, but rather focus ...

Artificial metalloenzymes (ArMs) are created by embedding a synthetic metal catalyst into protein scaffold. ArMs have the potential to merge catalytic advantages of natural enzymes with reaction scope catalysts. The choice scaffold is utmost importance tune activity ArM. Herein, we show repurposing HaloTag, self-labeling widely used in chemical biology, create an ArM for metathesis. This monome...

Given that oral consonants often block total vowel assimilation (Aoki 1968, Steriade 1987), this case of metathesis can be analyzed as serving to allow assimilation to apply unimpeded (cf. Broselow 2001). In terms of Optimality Theory, both the constraint driving assimilation and the constraint blocking assimilation across an oral consonant are satisfied, at the cost of violating faithfulness c...