basal cell carcinoma (bcc) is the most common cancer among humans, and the standard treatment is surgery. other modalities are reserved as a second line of treatment. topical chemotherapy may be used in primary bcc. systemic chemotherapy has no role in the primary treatment of bcc, although it may be efficacious in metastatic cases. we report the case of a patient with persistent recurrent bcc ...

INTRODUCTION Several studies evaluated the relation between colorectal cancer prognosis and various factors such as: depth of tumor invasion, involved lymph nodes size, counts and locations, metastatic nest expansion. We assessed the prognostic significance of the ratio between metastatic nest and involved lymph node diameter in colorectal cancer cases. METHODS A historical cohort study was c...

Emerging evidence implicates that a large fraction of human genome was transcribed but the transcripts known as long non coding RNA are not translated into proteins. They are contributing in different cellular processes, including cellular proliferation and apoptosis. LncRNAs were found to play critical roles in many diseases and act as key regulators in malignancies. In this study, we investig...

Treatment of metastatic prostate cancer has evolved significantly over the past decade. Palliative therapy has, historically, consisted androgen deprivation, chemotherapy and different radiation approaches. More recently, breakthrough with use poly-ADP-ribose polymerase (PARP) inhibitors led to significant improvement in outcome patients who harbor certain genetic mutations. This concise review...

In the United States, 1987 estimates of cancer incidence by site indicate that prostatic is equal to lung as first in adult males. Over 90,000 new cases are diagnosed and between 25-30,000 patients die this disease each year. While early a surgically curable disease, majority present with widely metastatic cancer, where main objective treatment palliation.

PURPOSE Metastatic prostate cancer is a major cause of death of men in the United States. Expression of met, a receptor tyrosine kinase, has been associated with progression of prostate cancer. EXPERIMENTAL DESIGN To investigate met as a biomarker of disease progression, urinary met was evaluated via ELISA in men with localized (n = 75) and metastatic (n = 81) prostate cancer. Boxplot analysi...

Only a minority of cancer cells have the potential to initiate metastatic growth, but the factors that limit metastatic colonization remain mostly unknown. Malanchi et al. (2012) recently demonstrated that stromal periostin is crucial for metastatic colonization by regulating the interactions between breast cancer stem cells and their metastatic niche.

background : this study retrospectively evaluated the prognostic factors and treatment outcome of patients with hormone-refractory prostate cancer who received chemotherapy. methods :we reviewed records of hormone-refractory prostate cancer patients who received chemotherapy between december 2004 and may 2011 at the clinical oncology and nuclear medicine department, mansoura university and the ...

Melanoma is originating from melanocytes, it a malignant tumor with high metastatic potential. It the leading cause of moratlity skin cancer, Nail melanoma rare form melanoma. we report new case this localization

INTRODUCTION The 2016 Coffey-Holden Prostate Cancer Academy (CHPCA) Meeting, "Beyond Seed and Soil: Understanding and Targeting Metastatic Prostate Cancer," was held from June 23 to June 26, 2016, in Coronado, California. METHODS For the 4th year in a row, the Prostate Cancer Foundation (PCF) hosted the CHPCA Meeting, a think tank-structured scientific conference, which focuses on a specific ...