Introduction In this era of modern medicine, antimicrobial resistance can be regarded as a major health calamity. The emergence multidrug-resistant (MDR) Pseudomonas aeruginosa strains poses therapeutic challenges and lead to treatment failure in hospitalized patients. This study was conducted determine various types β-lactamases among MDR P. isolates recovered from patients.
 MethodsThis ...

Migratory birds have been postulated as potential spreaders of antibiotic resistance. Multidrug-resistant Cellulosimicrobium sp. strain KWT-B was isolated from the feces of Hirundo rustica A draft genome sequence indicated that the strain harbors multidrug-resistant transporters, multidrug efflux pumps, a vancomycin-resistant protein, and metallo-beta-lactamases.

Pseudomonas aeruginosa is one of the commonest multi drug resistant bacteria causing nosocomial infection and Metallo-Beta-Lactamase production is one of the important reasons. The following study was conducted to determine incidence of MBL producing P.aeruginosa. and co existence of AmpC and ESBL production. Screening for MBL was done using imipenem disk and all the isolates found resistant we...

INTRODUCTION: We compared the prevalence and antimicrobial susceptibility of non-fermenting gram-negative bacilli (NFGNB) isolated from clinical samples at a Brazilian tertiary care hospital in 2008 and 2013. METHODS: Collected data included patient's name, age, sex, inpatient unit, laboratory record number, type of biological material, culture test result, and antimicrobial susceptibility of...

OBJECTIVE In India, Elores (CSE-1034: ceftriaxone+sulbactam+disodium edetate) was approved as a broad spectrum antibiotic in year 2011 and is used for management of Extended Spectrum Beta Lactamases/Metallo Beta lactamases infections in tertiary care centers. The objective of this study was to investigate the efficacy of this drug in patients with Extended Spectrum Beta Lactamases/Metallo Beta ...

The development of broad-spectrum metallo-beta-lactamase (MBL) inhibitors is challenging due to structural diversity and differences in metal utilisation by these enzymes. Analysis of structural data, followed by non-denturing mass spectrometric analyses, identified thiols proposed to inhibit representative MBLs from all three sub-classes: B1, B2 and B3. Solution analyses led to the identificat...

Background & Objective: The spread of carbapenem-resistant Pseudomonas aeruginosa is a global concern. Metallo-beta-lactamase (MBL) enzymes cause extensive drug resistance among Gram-negative bacteria. The current study aimed at determining the prevalence of MBL-producing P. aeruginosa in Iran. Methods<...

Enterobacteriaceae species are important human pathogens while increasing number of antibiotic resistant strains are detected worldwide. The most common antibiotic resistance in Enterobacteriaceae is observed against beta-lactams, fluoroquinolones, aminoglycosides while recently resistance to polymyxins has also appeared. Beta-lactam resistance is mainly conferred by beta-lactamases, capable to...

MBL production has been increasingly reported among Pseudomonas aeruginosa, which is an important nosocomial multidrug resistant pathogen. 2,3 Metallo beta lactamase (MBL) belongs to Ambler class B enzymes. With the help of divalent cation zinc as cofactor for enzymatic activity, they hydrolyze carbapenem as-well-as other blactam antibiotics. The substrate spectrum of this enzyme is quite broad...