The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alpha-synuclein belongs to the homologous synuclein family, which includes beta-synuclein. It has been proposed that beta-synuclein may be a natural regulator of alpha-synuclein. Therefore controlling beta-synuclein expression may control the accumulation of alpha-synuclein and ultim...

Funded by the U.S. Department of Energy, the Nuclear Energy Advanced Modeling and Simulation (NEAMS) program aims to develop an integrated multiphysics simulation capability “pellet to plant” for the design and analysis of future generations of nuclear power plants. NEAMS embraces a multiresolution hierarchy designing the code suite structure to ultimately span the full range of length and time...

The impact of numerical methods, particularly, the Finite Element Method (FEM), in providing tribological information relevant for lubricant formulations and general study of tribological variables is discussed. FEA was used to study surface evolution at the tool-workpiece interface for tube hydroforming and forging processes. The study has demonstrated that material properties, geometric compl...

We model the evolution of the abundances of light elements in carbon-enhanced metalpoor (CEMP) stars, under the assumption that such stars are formed by mass transfer in a binary system. We have modelled the accretion of material ejected by an asymptotic giant branch star on to the surface of a companion star. We then examine three different scenarios: one in which the material is mixed only by...

The forming limit diagram (FLD) is probably the most common representation of sheet metal formability and can be defined as the locus of the principal planar strains where failure is most likely to occur. Low carbon steel sheets have many applications in industries, especially in automotive parts, therefore it is necessary to study the formability of these steel sheets. In this paper, FLDs, wer...

The scientific importance of nanocomposites are being increased due to their improvedproperties. This paper is divided into two parts. First, Al-Al2O3 nanocomposite wasproduced by using ball milling technique followed by cold compaction and sintering.Microstructure and morphology studies were done through SEM, TEM, and EDX anal-ysis on the produced powder. The mechanical properties of the produ...