Osmotically controlled oral drug delivery systems utilize osmotic pressure for controlled delivery of active agents[3]. These systems can be utilized for systemic as well as targeted delivery of drugs. The release of drugs from osmotic system is governed by various formulation factors such as the solubility and the osmotic pressure of the core components, nature of the rate controlling membrane...

Various approaches to solvent recovery have been studied for the manufacturing process of celecoxib, the active ingredient in Celebrex. A design case study has been performed by Rowan University with Pfizer through a green engineering partnership program. The manufacturing operation at Barceloneta, Puerto Rico was evaluated and several green engineering alternatives for the purification and rec...

Albumin plays an important role in maintaining homeostasis within the body and depends on the cell membrane and the transport mechanism, including diffusion, osmosis, filtration, and active transport. The dissolved proteins, which are the only substances that do not penetrate the pores of the capillary membrane, are responsible for the osmotic pressure of the capillary membrane. Approximately 7...

The innovative design and synthesis of nanofiber based hydro-philic/phobic membranes with a thin hydro-phobic nanofiber layer on the top and a thin hydrophilic nanofiber layer on the bottom of the conventional casted micro-porous layer which opens up a solution for membrane pore wetting and improves the pure water flux in membrane distillation.

Microporous membranes fabricated from hydrophobic polymers such as polyvinylidene fluoride (PVDF) have been widely used for membrane distillation (MD). However, hydrophobic MD membranes are prone to wetting by low surface tension substances, thereby limiting their use in treating challenging industrial wastewaters, such as shale gas produced water. In this study, we present a facile and scalabl...

Qatar’s primary source of fresh water is through seawater desalination. Amongst the major processes that are commercially available on the market, the most common large scale techniques are Multi-Stage Flash distillation (MSF), Multi Effect distillation (MED), and Reverse Osmosis (RO). Although commonly used, these three processes are highly expensive down to high energy input requirements and ...

Direct contact membrane distillation (DCMD) which emerges as an alternative separation technology can effectively perform a colloidal separation process under thermal driven force. DCMD is capable of extracting pure water from aqueous solutions containing non-volatile nanoparticles through the hydrophobic microporous membrane when a vapour pressure difference was established across the membrane...

High liquid entry pressure (LEP) is one of the desired characteristics of a membrane distillation (MD) membrane. Maintaining LEP above operating feed pressure conditions is critical to prevent permeate quality worsening by saline feed liquid passage through the membrane. Air gap membrane distillation experiments under controlled salinity and temperature operating conditions indicate that in add...

When osmotic pressure across an artificial membrane, produced by a permeable electrically neutral solute on one side of it, is balanced by an external pressure difference so that there is no net volume flow across the membrane, it has been found that there will be a net flux of a second electrically neutral tracer solute, present at equal concentrations on either side of the membrane, in the di...

Membrane technology is growing very fast and it is used in several main applications from desalination, water and wastewater treatment to medical, biotechnology and gas separation field. Different membrane processes are applied depending on the applications from more traditional pressure-driven membrane processes (Microfiltration, MF; Ultrafiltration, UF; Nanofiltration, NF) to more advanced on...