Objectives: Mitochondrial disorders (MIDs) are usually multisystem diseases and may manifest in addition to other systems also in the vasculature. Method: Literature review by using appropriate key words. Results: Vasculopathy in MIDs particularly manifests in arteries in form of a macroor microangiopathy. Direct evidence for microangiopathy in MIDs derives from the following findings: histolog...

The precise mechanism of neurological symptoms in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is still controversial. The diffusion weighted MR findings at the acute phase of a neurological event in MELAS are described and the pathophysiology of stroke-like lesion in the light of diffusion changes is discussed. Brain MRI was performed ...

AIM To evaluate the feasibility of microRNAs (miR) in clinical use to fill in the gap of current methodology commonly used to test hearing impairment in MELAS patients. MATERIAL AND METHOD A literature review was performed using the following keywords, i.e., MELAS, Hearing Loss, Hearing Impairment, Temporal Bone, Otoacustic Emission (OTOAE), Auditory Brain Response (ABR), and microRNA. We rev...

Mitochondrial encephalopathies (MEs) are characterized by an extreme clinical heterogeneity since they can involve different systems and manifest at distinct ages with variable course. Many affected individuals display a cluster of clinical features that fall into discrete syndromes among syndromic pictures, epilepsy is relevant in myoclonic epilepsy with ragged-red fibers (MERRF), mitochondria...

The Tablas de Daimiel National Park (TDNP) is a floodplain ecosystem in central Spain with potential risk of heavy metal and metalloid pollution. objective this study was to know the accumulation arsenic (As), cadmium (Cd), mercury (Hg), lead (Pb), selenium (Se) muscle six species freshwater fish from TDNP. We obtained samples Cyprinus carpio (n = 89); Squalius pyrenaicus 16); Ameiurus melas 9)...

OBJECTIVE There is a paucity of objective, quantifiable indicators of mitochondrial disease available for clinical and scientific investigation. METHODS To this end, we explore intramyocellular lipid (IMCL) accumulation noninvasively by 7T magnetic resonance spectroscopy (MRS) as a reporter of metabolic dysfunction in MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like ep...