نتایج جستجو برای: melanoma cancer

تعداد نتایج: 949274  

Journal: :Journal of Investigative Dermatology 2023

Melanoma is the most aggressive skin cancer and responsible for majority of deaths. Despite advances in treatment, our current prognostic indicators are poor fail to adequately risk-stratify patients. This study evaluates concentration, size, proteomic metabolomic profile circulating extracellular vesicles (EVs) isolated from plasma patients with melanoma, identify potential biomarkers disease ...

Journal: :Journal of Investigative Dermatology 2022

Melanoma, an aggressive malignancy of melanocytes, is responsible for more deaths than any other skin cancer. Despite the fact that there a long lag period before premalignant dysplastic nevi become invasive melanomas, has been little progress in developing new methods melanoma prevention. Using animal model melanomagenesis, we examined whether administration anti-PD-L1 antibodies, effective im...

2014
Anja Ulmer Klaus Dietz Isabelle Hodak Bernhard Polzer Sebastian Scheitler Murat Yildiz Zbigniew Czyz Petra Lehnert Tanja Fehm Christian Hafner Stefan Schanz Martin Röcken Claus Garbe Helmut Breuninger Gerhard Fierlbeck Christoph A. Klein

BACKGROUND Sentinel lymph node spread is a crucial factor in melanoma outcome. We aimed to define the impact of minimal cancer spread and of increasing numbers of disseminated cancer cells on melanoma-specific survival. METHODS AND FINDINGS We analyzed 1,834 sentinel nodes from 1,027 patients with ultrasound node-negative melanoma who underwent sentinel node biopsy between February 8, 2000, a...

Journal: :Cancers 2023

Melanoma is an aggressive form of skin cancer resulting from the malignant transformation melanocytes. Recent therapeutic approaches, including targeted therapy and immunotherapy, have improved prognosis outcome melanoma patients. BRAF one most frequently mutated oncogenes recognised in melanoma. The frequent oncogenic mutations consist a single point mutation at codon 600 (mostly V600E) that l...

Journal: :Neuro-oncology 2022

Abstract Melanoma is third most common cancer to metastasize the leptomeningeal space and confers a dismal prognosis. We retrospectively identified 87 cases of melanoma related disease (M-LMD) diagnosed between 2011-2020 at Moffitt Cancer Center. The average age diagnosis was 54 years (range 28-93 years) with male predominance (50 men vs 36 women). There significant increase in median overall s...

2014
Karli Rosner Shreelekha Adsule Brittany Haynes Evangelia Kirou Ikuko Kato Darius R. Mehregan Malathy P.V. Shekhar

Melanoma is the leading cause of death from skin cancer in industrialized countries. Several melanoma-related biomarkers and signaling pathways have been identified; however, their relevance to melanoma development/progression or to clinical outcome remains to be established. Aberrant activation of Wnt/β-catenin pathway is implicated in various cancers including melanoma. We have previously dem...

 Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catecho...

Journal: :Pigment cell & melanoma research 2011
Deeba N Syed Hasan Mukhtar

Cutaneous melanoma, a cancer of melanocytes, when detected at later stages is arguably one of the most lethal cancers and the cause of more years of lost life than any other cancer among young adults. There is no standard therapy for advanced-stage melanoma and the median survival time for patients with metastatic melanoma is <1 yr. An urgent need for novel strategies against melanoma has direc...

2015
Laurent Lessard Michelle Liu Diego M. Marzese Hongwei Wang Kelly Chong Neal Kawas Nicholas C Donovan Eiji Kiyohara Sandy Hsu Nellie Nelson Sivan Izraely Orit Sagi-Assif Isaac P Witz Xiao-Jun Ma Yuling Luo Dave SB Hoon

In recent years, considerable advances have been made in the characterization of protein-coding alterations involved in the pathogenesis of melanoma. However, despite their growing implication in cancer, little is known about the role of long noncoding RNAs in melanoma progression. We hypothesized that copy number alterations (CNAs) of intergenic nonprotein-coding domains could help identify lo...

2015
Gery P. Guy Cheryll C. Thomas Trevor Thompson Meg Watson Greta M. Massetti Lisa C. Richardson

BACKGROUND Melanoma incidence rates have continued to increase in the United States, and risk behaviors remain high. Melanoma is responsible for the most skin cancer deaths, with about 9,000 persons dying from it each year. METHODS CDC analyzed current (2011) melanoma incidence and mortality data, and projected melanoma incidence, mortality, and the cost of treating newly diagnosed melanomas ...

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