In xiphophorine fish suffering from a genetically caused melanoma, both suppression of melanoma development and regression of the existing melanoma were observed after treatment of the fish with an "anti-melanoma immune RNA." This RNA was extracted from the lymphoid organs of guinea pigs immunized with fish melanoma. RNA from guinea pigs immunized with fish skin or liver and RNA from nonimmuniz...

Melanoma is the most aggressive skin cancer and responsible for majority of deaths. Despite advances in treatment, our current prognostic indicators are poor fail to adequately risk-stratify patients. This study evaluates concentration, size, proteomic metabolomic profile circulating extracellular vesicles (EVs) isolated from plasma patients with melanoma, identify potential biomarkers disease ...

Melanoma, an aggressive malignancy of melanocytes, is responsible for more deaths than any other skin cancer. Despite the fact that there a long lag period before premalignant dysplastic nevi become invasive melanomas, has been little progress in developing new methods melanoma prevention. Using animal model melanomagenesis, we examined whether administration anti-PD-L1 antibodies, effective im...

Introduction: Treatment with immune checkpoint inhibitors in melanoma patients can cause immune-related adverse effects, such as vitiligo. In vitiligo, specific autoimmunity against melanocytes results depigmentation of the skin. Melanoma-associated vitiligo occurring treated be seen a good prognostic sign higher survival rates melanoma-associated cases have been reported.Areas covered: This re...

In this work, Raman and autofluorescence spectroscopy in the near-infrared region has been used for examining amelanotic melanoma as most dangerous type of malignant melanoma. There were 9 patients with melanoma, 60 pigmented 120 basal cell carcinoma enrolled study. We studied cases to differentiate them from (n = 120) 60) using portable setup laser excitation source at 785 nm low-cost spectrom...

Madam, Melanoma, the most lethal skin cancer, accounts for 75% of deaths by cancer in US.1 Nivolumab, Pembrolizumab, and a combination Nivolumab ipilimumab are used adjuvant therapy distant metastatic melanoma.2 The nivolumab melanoma per patient month was estimated to be USD 71,689.3 Nevertheless, efficiency these treatments is limited.4 Furthermore, metastasis can reduce effectiveness treatme...

BACKGROUND Subtypes of melanoma, such as mucosal, uveal, and acral, are believed to result in worse prognoses than nonacral cutaneous melanoma. After a diagnosis of distant metastatic disease, however, the overall survival of patients with mucosal, uveal, acral, nonacral cutaneous, and unknown primary melanoma has not been directly compared. MATERIALS AND METHODS We conducted a single-center,...

Tests of cell mediated immunity (one and two stage leucocyte migration inhibition assays) and humoural immunity (membrane immunofluorescence and serum effects on leucocyte migration) were done with leucocytes and sera from 36 patients with uveal melanoma, five with conjunctival melanoma, 21 with non-malignant ocular disease, and 189 with cutaneous melanoma. Cell mediated reactivity with melanom...

Choroidal melanoma is one of the most malignant tumors organ vision, development which associated with risk metastasis and possibility death, indicates relevance search application effective methods treatment this pathology. To date, in choroidal melanoma, preference given to organ-preserving aimed at achieving local control over tumor. One promising techniques photodynamic therapy, a method ba...

AIM In this review, we outline similarities between conjunctival and skin melanoma as well as the effectiveness of combined BRAF/MEK inhibition in melanoma, and discuss the applicability of these agents in conjunctival melanoma. METHODS The study provides a PubMed literature review. RESULTS Conjunctival melanoma and skin melanoma are genetically and phenotypically related. Both tumors typic...