High-dose melphalan 200 mg/m(2) (MEL 200) is the standard of care as a conditioning regimen for autologous hematopoietic stem cell transplantation (AHSCT) for multiple myeloma (MM). We compared a novel conditioning combination incorporating busulfan, melphalan, and bortezomib (BUMELVEL) versus standard MEL 200 in newly diagnosed patients undergoing AHSCT for MM. Between July 2009 and May 2012, ...

While generative adversarial networks (GANs) based neural text-to-speech (TTS) systems have shown significant improvement in speech synthesis, there is no TTS system to learn synthesize from text sequences with only feedback. Because feedback alone not sufficient train the generator, current models still require reconstruction loss compared ground-truth and generated mel-spectrogram directly. I...

The present pre- and postnatal study was carried out to investigate the effect of melatonin (MEL), a potent antioxidant, on biochemical variables in the in vivo model of intrauterine hypoxia in rats. Chronic hypoxia was induced pharmacologically by the administration of the anticonvulsant phenytoin (PHT) during pregnancy. Rats were orally treated by PHT (150 mg/kg) from day 7 to 18 of gestation...

BACKGROUND Mannosylerythritol lipids (MEL) are glycolipids with unique biosurfactant properties and are produced by Pseudozyma spp. from different substrates, preferably vegetable oils, but also sugars, glycerol or hydrocarbons. However, solvent intensive downstream processing and the relatively high prices of raw materials currently used for MEL production are drawbacks in its sustainable comm...

This directory contains the Neuron code for the CA1 pyramidal cell model and the experiments described in: 1. Poirazi, P. Brannon, T. & Mel, B.W. Arithmetic of Subthreshold Synaptic Summation in a Model CA1 Pyramidal Cell. In Press, Neuron , February 2003. 2. Poirazi, P. Brannon, T. & Mel, B.W. Online Supplement: About the Model. In Press, Neuron , February 2003. 3. Poirazi, P. Brannon, T. & Me...

On July 1, 1970, I started my fellowship in neonatology under the tutelage of Mary Ellen Avery. I entered her lab in the MacIntyre Building at McGill University in Montreal. There were no other fellows or techs working in her lab at the time. The lab was spacious but sparsely furnished. In one corner was a pneumatic surface balance, handbuilt, from the design of John Clements. A lab book lay on...

This study examined the pharmacokinetics and analgesic effect of oral meloxicam (MEL) administered alone or in combination with gabapentin (GABA) in an experimental bovine lameness model. Eighteen male British × Continental beef calves aged 4 to 6 mo and weighing 297 to 392 kg were randomly assigned to receive either 1) 0.5 mg/kg lactose monohydrate placebo (PLBO; n = 6), 2) 0.5 mg/kg MEL (n = ...

A safer, more effective adulticidal treatment and a safe method for reducing microfilaremia and breaking transmission of heartworm disease early in the treatment are needed. The present study evaluated efficacy of ivermectin (IVM) and doxycycline (DOXY) alone or together (with or without melarsomine [MEL]) in dogs with induced adult heartworm infection and assessed the ability of microfilariae ...