A 22 year old unbooked female patient presented to our Prince Hashem Hospital in Al-Zarqa with labor pain. The patient was admitted to our labor room and delivered normally. Diagnosis of megaloblastic anemia was made after she developed left eye macular hemorrhage on the second day of delivery and confirmed by bone marrow biopsy.

Myelodysplastic syndrome (MDS) is composed of a group of diseases that for decades have been challenging to diagnose and manage. MDS is a clonal disease of the bone marrow. The pathologic manifestation of morphologic abnormalities (dysplasia) include ringed sideroblasts, megaloblastic changes, pseudo-Pelger cells, and micromega and multinucleated megakaryocytes. The clinical spectrum ranges fro...

BACKGROUND Transcobalamin II is a serum transport protein for vitamin B12. Small variations in TC-II affinity were recently linked to a high homocysteine level and increased frequency of neural tube defects. Complete absence of TC-II or total functional abnormality causes tissue vitamin B12 deficiency resulting in a severe disease with megaloblastic anemia and immunologic and intestinal abnorma...

T HE PROFOUND alteration in human erythrobbasts in folic acid or vitamm B12 deficiency is manifest to an important degree by the appearance of the interphase nuclear chromatin in the megaloblastic cells. This is reflected in the appearance of the individual chromosomes, and it is generally agreed that the chromosomes of megaloblasts differ in morphologic details from those of normoblasts. Rohrt...

By S. ARDEMAN, I. CIIANARIN AND A. \V. FRANKLAND T HE Pelger-Huet anomaly of Ieukocytcs is characterized by the ence of tii oval, indented or bibbed ( “pincc-nez” ) nucleus in the neutrophil polymorphonuclear leukocytes which replaces the normal nuclear segmentation of these cells ( Pelger’ ) . It is inherited as an autosomal dominant characteristic ( Hu#{235}t2 ) , the incidence being 1 in 600...

Congenital methylmalonic aciduria-homocystinuria, a disorder with an incompletely defined cobalamin abnormality. has not been accompanied by megaloblastosis in most of the initially described cases. This has raised questions about the exact role of cobalamin in relation to megaloblastic anemia. Therefore, we present our observations on a patient with this syndrome whose manifestations conformed...

HILE the umsderhyimmg causes of the nsajority of misegaloblast-ic amsemssias are usow knsown, the list is usotyet exhaustive amid it has recemstly been suggested that amsticomsvulsammt drutgs nsay commstitute a mies ’ etiohogic fact-or its sonic cases. The postulated effectof these drutgs is particutlarly strikimsg ins that megaloblastic ausemia is msot seems wit-h the niomispecific toxic agcmm...