The strength and stability of hybrid fiber delivery systems, ones that perform a mechanical function and simultaneously deliver drug, are critical in the design of surgically implantable constructs. We report the fabrication of drug-eluting microfibers where drug loading and processing conditions alone increase microfiber strength and stability partially due to solvent-induced crystallization. ...

Single-molecule force spectroscopy studies and steered molecular dynamics simulations have revealed that protein topology and pulling geometry play important roles in determining the mechanical stability of proteins. Most studies have focused on local interactions that are associated with the force-bearing beta-strands. Interactions mediated by neighboring strands are often overlooked. Here we ...

Electron beam stability is very important for third-generation light sources, especially for the Shanghai Synchrotron Radiation Facility whose ground vibrations are much larger than those for other light sources. Beam position monitors (BPMs), used to monitor the position of the electron beam, require a greater stability than other mechanical structures. This paper concentrates on an investigat...

Many viruses use programmed -1 ribosomal frameshifting to express defined ratios of structural and enzymatic proteins. Pseudoknot structures in messenger RNAs stimulate frameshifting in upstream slippery sequences. The detailed molecular determinants of pseudoknot mechanical stability and frameshifting efficiency are not well understood. Here we use single-molecule unfolding studies by optical ...

Titin I27 shows a high resistance to unfolding when subject to external force. To investigate the molecular basis of this mechanical stability, protein engineering Phi-value analysis has been combined with atomic force microscopy to investigate the structure of the barrier to forced unfolding. The results indicate that the transition state for forced unfolding is significantly structured, since...

In this work, nonlocal vibration of double of carbon nanotubes (CNTs) system conveying fluid coupled by visco-Pasternak medium is carried out based on nonlocal elasticity theory where CNTs are placed in uniform temperature change and magnetic field. Considering Euler-Bernoulli beam (EBB) model and Knudsen number, the governing equations of motion are discretized and Ritz method is applied to ob...

We present the first single-molecule atomic force microscopy study on the effect of chemical denaturants on the mechanical folding/unfolding kinetics of a small protein GB1 (the B1 immunoglobulin-binding domain of protein G from Streptococcus). Upon increasing the concentration of the chemical denaturant guanidinium chloride (GdmCl), we observed a systematic decrease in the mechanical stability...

Finding a suitable estimation of stability domain around stable equilibrium points is an important issue in the study of nonlinear dynamical systems. This paper intends to apply a set of analytical-numerical methods to estimate the region of attraction for autonomous nonlinear systems. In mechanical and structural engineering, autonomous systems could be found in large deformation problems or c...

In this paper Power system stability enhancement through static synchronous compensator (STATCOM)based controller is investigated. The potential of the STATCOM supplementary controllers to enhance thedynamic stability is evaluated. The design problem of STATCOM based damping controller is formulatedas an optimization problem according to the eigenvalue based objective function that is solved by...