background and aims: measles remains one of the leading causes of childhood morbidity and mortality in developing countries and is still a major public health concern in developed countries. although live attenuated vaccine is used throughout the world, out breaks of disease still occur in many countries including iran. methods: the present study was performed to evaluate the immune status agai...

A new, further attenuated measles vaccine, developed by propagation of Edmonston B measles virus in the chorioallantoic membrane in ovo, has been clinically evaluated in children and found to compare favorably with a commercially available product. The vaccine is prepared in chick embryo tissue culture and appears to possess noteworthy stability at 4 C.

Previously controlled vaccine preventable diseases (VPDs) are in resurgence. To date, there have been 477 confirmed measles cases in the United States in 2014, the most in 18 years. In 2013 there were ∼25 000 pertussis cases in the United States. Vaccine refusal has been associated with outbreaks of invasive Haemophilus influenzae type b disease, varicella, pneumococcal disease, measles, and pe...

measles is a highly contagious disease. by the end of 2013, 84% of children had received at least a single dose of measles vaccine by their second birthday, and 148 countries had included a second dose as part of routine immunization. in 2002, the iranian ministry of health and medical education developed a comprehensive strategy to eliminate measles including mass immunization campaign for peo...

OBJECTIVES To determine morbidity and mortality from measles and to estimate measles vaccine effectiveness among children hospitalised with measles in two hospitals in Nairobi. DESIGN A review of hospital records (index cards). SETTING Kenyatta National Hospital and Mbagathi District Hospitals covering the years 1996-2000. METHOD A review of index cards for measles morbility and mortality...

1993 Marks Fewest Reported Measles Cases in U.S. As of July 3, 1993, (week 26), local and state health departments reported a provisional total of 167 measles cases for 1993-the lowest total reported for the first 26 weeks of any year since surveillance began in 1943. The represents a 99% decrease from the 13,787 cases reported during the first 26 weeks of 1990, the peak of the recent resurgenc...

Stability studies play a critical role in assuring product quality at all points in the vaccine life cycle and havea major impact on the success of immunization programs worldwide. The purpose of stability study isdetermination of the vaccine quality under the variety of environmental factors and to establish a re-testperiod or a shelf life and recommended storage conditions. In this study thre...

conclusions results indicated that the present vaccination program is insufficient for immunity against measles in this area. the general population immunity was lower than the necessary level for the elimination of measles. therefore, sero-epidemiological studies are necessary to organize national programs for control and elimination of measles. results overall, 821 (91.2%) of the studied popu...

BACKGROUND The persistence of antibodies against measles, mumps, and rubella induced by the measles-mumps-rubella (MMR) vaccine and the kinetics of antibody decline after the second MMR vaccine dose were studied in the same cohort for 20 years. METHODS Measles, mumps, and rubella antibodies were measured by enzyme immunoassay in 20-year follow-up serum samples (n= 183) of twice-vaccinated ind...

BACKGROUND Cytokines are key regulators of measles vaccine humoral and cellular immunity. Single-nucleotide polymorphisms (SNPs) that are associated with differences in cytokine levels should also influence measles vaccine-induced immunity. METHODS We genotyped 118 measles-mumps-rubella-vaccinated subjects for SNPs from 6 cytokine genes (interleukin [IL]-2, IL-4, IL-10, IL-12A, IL-12B, and in...