A bacterioferritin (BFR) deletion mutant of Brucella melitensis 16M was generated by gene replacement. The deletion was complemented with a broad-host-range vector carrying the wild-type bfr gene, pBBR-bfr. The survival and growth of the mutant, B. melitensis PAD 2-78, were similar to those of its parental strain in human monocyte-derived macrophages (MDM). These results suggest that BFR is not...

The paper presents a: a) brief overview and analysis of existing approaches to the data warehouse (DW) evolution problem, and b) detailed description of the research idea for the DW evolution problem (primarily intended for structured data sources and realizations with relational database engines). We observe the DW evolution problem as a double issue from the DW perspective, and from the maste...

Primary human monocyte-derived macrophages (MDM) were shown to have diminished deoxynucleoside kinase activities compared to T lymphoblasts, and a reduced ability to phosphorylate dideoxynucleosides with anti-human immunodeficiency virus (HIV) activity. These drugs, azidothymidine (AZT), dideoxycytidine (ddC), and dideoxyadenosine (ddA), which are potent anti-HIV agents in CD4 lymphocytes, did ...

We theoretically investigate the properties of absorption switches for metal-dielectric-metal (MDM) plasmonic waveguides. We show that a MDM waveguide directly coupled to a cavity filled with an active material with tunable absorption coefficient can act as an absorption switch, in which the on/off states correspond to the absence/presence of optical pumping. We also show that a MDM plasmonic w...

In this study levels of prostaglandin E(2) (PGE(2)), tumour necrosis factor (TNF) and interleukin-1 (IL-1) alpha in medium from monocyte derived macrophages (MdM) infected with Chlamydia trachomatis (L(2)/434/Bu or K biovars). TNF and PGE(2) were found in both cases while IL-1 alpha was not detected. Both TNF and PGE(2) levels were higher in the medium of the MdM infected with K biovars. TNF re...

Macrophage-derived chemokine (MDC) has been reported to inhibit different HIV-1 strains in activated peripheral blood mononuclear cells (T cell blasts), although other investigators have not confirmed these findings. Here we demonstrate that MDC inhibits the replication of CCR5-dependent (R5) HIV-1(BaL) in monocyte-derived macrophages (MDM), but not in T cell blasts, although with variable pote...

SVMtraining is usually discussed under twodifferent algorithmic points of view. The first one is provided by decomposition methods such as SMO and SVMLight while the second one encompasses geometric methods that try to solve a Nearest Point Problem (NPP), the Gilbert– Schlesinger–Kozinec (GSK) andMitchell–Demyanov–Malozemov (MDM) algorithms being the most representative ones. In this work we wi...

We successfully fabricate three-mode erbium doped fiber with a confined Er(3+) doped ring structure and experimentally characterize the amplifier performance with a view to mode-division multiplexed (MDM) transmission. The differential modal gain was effectively mitigated by controlling the relative thickness of the ring-doped layer in the active fiber and pump launch conditions. A detailed stu...

Résumé. Dans cet article, nous proposons un formalisme permettant à des utilisateurs d’être impliqués dans les phases de conception de modèles de Gestion de Données de Référence (dite MDM), tout en faisant abstraction des spécificités techniques de la plateforme cible. Pour cela, des profils sont définis pour étendre la sémantique d’UML, trop générique, à celle du MDM par l’intermédiaire d’un p...

Nowadays, organizations deal with multiple data sources. Therefore, they must cope with data quality problems such as inconsistent and inaccurate data, as well as with data integration and synchronization. In this paper, we present an implementation of an MDM architecture using the open source tool Mural. Furthermore, we report preliminary experimental results that demonstrate the advantages of...