OBJECTIVE The oxidant/antioxidant state in septic patients has only been studied in small series. We wished to determine whether malondialdehyde (MDA) serum levels were associated with severity and 30-day mortality in a large series of patients with sepsis. METHODS We performed an observational, prospective, multicenter study in six Spanish Intensive Care Units. Serum levels of MDA were measu...

are refined mostly by MDA tools towards lower-level The Model Driven Architecture (MDA), as propagated by the Object Management Group, is often considered to be a milestone towards model-based development. This paper argues that MDA should merely be seen as an intermediate phase towards a truly architecture-based approach to software development. Model-based development will only succeed if we ...

One purpose of this paper is to propose the hybrid neural network models for bankruptcy prediction. The proposed hybrid neural network models are, respectively, a MDA model integrated with financial ratios, a MDA model integrated with financial ratios and intellectual capital ratios, a MDA-assisted neural network model integrated with financial ratios, and a MDA-assisted neural network model in...

BACKGROUND Semaphorin 4D (Sema4D) is highly expressed in certain types of tumors and functions in the regulation of tumor angiogenesis and growth. However, it is still not clear regarding the roles of Sema4D in breast cancer. This study was designed to explore the effects of Sema4D on proliferation, cell cycle progression, apoptosis, invasion, migration, tumor growth, and angiogenesis in breast...

BACKGROUND Trachoma is the leading infectious cause of blindness worldwide. In communities where the district level prevalence of trachomatous inflammation-follicular among children ages 1-9 years is ≥5%, WHO recommends annual mass drug administration (MDA) of antibiotics with the aim of at least 80% coverage. Population-based post-MDA coverage surveys are essential to understand the effectiven...

The Mesocyclone Detection Algorithm (MDA) is used in the Weather Surveillance Radar –1988 Doppler (WSR-88D) to detect rotation associated with tornadoes and other severe weather. The MDA analyzes Doppler radar radial velocity volume scans to compose a number of attributes thought to be related to mesocyclone formation. The 23 attributes of the MDA are compared to truthed tornado data in explora...

Agents that generate reactive oxygen species (ROS) are recognized to enhance MDA-7/IL-24 lethality. The present studies focused on clarifying how such agents enhanced MDA-7/IL-24 toxicity in renal cell carcinoma cells (RCCs). Infection of RCCs with a tropism-modified serotype 5/3 adenovirus expressing MDA-7/IL-24 (Ad.5/3-mda-7) caused plasma membrane clustering of CD95 and CD95 association with...

OBJECTIVE To explore the relationship between minimal disease activity (MDA) and the low disease activity cutoffs of the Psoriatic ArthritiS Disease Activity Score (PASDAS) and the Composite Psoriatic Disease Activity Index (CPDAI). METHODS Data from the GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis) composite exercise (GRACE) study were used for these analyse...

Malondialdehyde (MDA) is one of the most frequently used indicators of lipid peroxidation. To generate reliable reference intervals for plasma malondialdehyde (P-MDA), a reference sample group was established in Funen, Denmark. The group consisted of 213 individuals (107 men, 106 women), ages 20-79 years. P-MDA was measured in EDTA-treated plasma after derivatization by thiobarbituric acid (TBA...

BACKGROUND The first-ever round of school-based mass drug administration (MDA) with praziquantel together with mebendazole targeting school-aged children in endemic districts was conducted in 2009 by the National Neglected Tropical Diseases Control Program. To evaluate the impact of the treatment regimen, a cross-sectional sentinel site survey was conducted 6 months post-MDA. METHODS Fifteen ...