نتایج جستجو برای: mda

تعداد نتایج: 20691  

2015
Leonardo Lorente María M. Martín Pedro Abreu-González Luis Ramos Mónica Argueso Jordi Solé-Violán Marta Riaño-Ruiz Alejandro Jiménez

OBJECTIVE Malondialdehyde (MDA) is an end-product formed during lipid peroxidation, due to degradation of cellular membrane phospholipids. MDA is released into extracellular space and finally into the blood; it has been used as an effective biomarker of lipid oxidation. High circulating levels of MDA have been previously described in patients with ischemic stoke than in controls, and an associa...

2013
Wilma A. Stolk Quirine A. ten Bosch Sake J. de Vlas Peter U. Fischer Gary J. Weil Ann S. Goldman

The Global Program to Eliminate Lymphatic Filariasis (LF) has a target date of 2020. This program is progressing well in many countries. However, progress has been slow in some countries, and others have not yet started their mass drug administration (MDA) programs. Acceleration is needed. We studied how increasing MDA frequency from once to twice per year would affect program duration and cost...

2015
Mitchell E. Menezes Xue-Ning Shen Swadesh K. Das Luni Emdad Chunqing Guo Fang Yuan You-Jun Li Michael C. Archer Eldad Zacksenhaus Jolene J. Windle Mark A. Subler Yaacov Ben-David Devanand Sarkar Xiang-Yang Wang Paul B. Fisher

Melanoma differentiation associated gene-7/Interleukin-24 (MDA-7/IL-24) is a novel member of the IL-10 gene family that selectively induces apoptosis and toxic autophagy in a broad spectrum of human cancers, including breast cancer, without harming normal cells or tissues. The ability to investigate the critical events underlying cancer initiation and progression, as well as the capacity to tes...

Journal: :Cancer research 2003
Shi Ke Xiaoxia Wen Michael Gurfinkel Chusilp Charnsangavej Sidney Wallace Eva M Sevick-Muraca Chun Li

The specificity of a novel epidermal growth factor (EGF)-Cy5.5 fluorescent optical probe in the detection of EGF receptor (EGFr) was assessed using continuous-wave fluorescence imaging accomplished via an intensified charge-coupled device (CCD) camera. Human mammary MDA-MB-468 (EGFr+) and MDA-MB-435 (EGFr-) cancer cells were incubated with Cy5.5, EGF-Cy5.5, or the anti-EGFr monoclonal antibody ...

2009
Christoph Herrmann Holger Krahn Bernhard Rumpe Martin Schindler Steven Völkel

Model-based development and in particular MDA [1], [2] have promised to be especially suited for the development of complex, heterogeneous, and large software systems. However, so far MDA has failed to fulfill this promise to a larger extent because of tool support being inadequate and clumsy and methodologies not being appropriate for an effective development. This article discusses what went ...

2018
Uta Hardt Anders Larsson Iva Gunnarsson Robert M Clancy Michelle Petri Jill P Buyon Gregg J Silverman Elisabet Svenungsson Caroline Grönwall

BACKGROUND Immunoglobulin M (IgM) autoreactivity to malondialdehyde (MDA) protein modifications is part of the natural antibody repertoire in health and may have beneficial functions. In contrast, IgG anti-MDA are increased in chronic inflammation and autoimmunity and may instead have pathogenic properties. METHODS Herein, we investigated serum IgG anti-MDA levels by enzyme-linked immunosorbe...

2017
Hyuna Kim Youngmi Kim Dooil Jeoung

Although cancer/testis antigen DDX53 confers anti-cancer drug-resistance, the effect of DDX53 on cancer stem cell-like properties and autophagy remains unknown. MDA-MB-231 (CD133+) cells showed higher expression of DDX53, SOX-2, NANOG and MDR1 than MDA-MB-231 (CD133-). DDX53 increased in vitro self-renewal activity of MCF-7 while decreasing expression of DDX53 by siRNA lowered in vitro self-ren...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
Habib Boukerche Zao-zhong Su Célia Prévot Devanand Sarkar Paul B Fisher

The scaffold PDZ-domain containing protein mda-9/syntenin functions as a positive regulator of cancer cell progression in human melanoma and other tumors. mda-9/Syntenin regulates cell motility and invasion by altering defined biochemical and signaling pathways, including focal adhesion kinase (FAK), p38 mitogen-activated protein kinase (MAPK) and NF-kappaB, but precisely how mda-9/syntenin org...

Journal: :Nucleic acids research 2003
Lovisa Lovmar Mona Fredriksson Ulrika Liljedahl Snaevar Sigurdsson Ann-Christine Syvänen

Whole genome amplification (WGA) procedures such as primer extension preamplification (PEP) or multiple displacement amplification (MDA) have the potential to provide an unlimited source of DNA for large-scale genetic studies. We have performed a quantitative evaluation of PEP and MDA for genotyping single nucleotide polymorphisms (SNPs) using multiplex, four-color fluorescent minisequencing in...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Min Yin Shuxi Liu Yanqing Yin Sen Li Zhihua Li Xuefei Wu Bo Zhang Siew-Lan Ang Yuqiang Ding Jiawei Zhou

Mesodiencephalic dopaminergic (mDA) neurons are critical for movement control and other physiological activities. However, the molecular mechanisms underlying their development are poorly understood. We aimed to establish the expression profiles of genes involved in this process and unravel genetic programs that control late development of mDA neurons. We compared genome-wide gene expression pr...

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