Objectives: To use health economic modeling techniques to quantify and compare the clinical and economic outcomes associated with the use of subcutaneous interferon beta-1a (scIFNβ 1a) vs. intramuscular interferon beta-1a (imIFNβ 1a) over 2 years in the management of relapsing forms of multiple sclerosis (MS) from a US health care payer perspective. MethOds: The 2-year decision analytic model w...

BACKGROUND The long-acting muscarinic antagonist (LAMA) umeclidinium (UMEC) and the combination of UMEC with the long-acting β2-agonist (LABA) vilanterol (UMEC/VI) are approved maintenance treatments for chronic obstructive pulmonary disease (COPD) in the US and EU. They are not indicated for the treatment of asthma. METHODS In this 52-week, double-blind, placebo-controlled, parallel-group sa...

Vol. 33 No. 10 • October 2008 • P&T® 567 programmed the bolus dose, but because the pump had been set incorrectly at a 1-mcg/mL of the 50-mcg/mL concentration, or 1,000 mcg! About 15 minutes later, the patient was found to be unresponsive and was quickly transferred to the intensive-care unit. The patient died three days later. In this fatal event, the two nurses had been familiar with fentanyl...

conclusions we observed no significant differences between the two groups in lipid and carbohydrate metabolism, except for hdl-c. considering the importance of overweight and obese women’s health, studies with longer follow-up periods are recommended in this respect. results the differences in lipid and carbohydrate parameters were not significant between the two groups, except for hdl-c (adjus...

BACKGROUND The combination of inhaled corticosteroids (ICS) and long-acting beta2-agonists (LABA) is recommended by treatment guidelines for the treatment of persistent asthma. Two such combination products, salmeterol/fluticasone propionate (SFC, Seretide GSK, UK) and formoterol/budesonide (FBC, Symbicort, AstraZeneca, UK) are commercially available. OBJECTIVES The purpose of these studies w...

Magnetocardiography (MCG) is a technique of measuring the weak magnetic fields generated in the heart during its functioning. MCG can be measured using a superconducting quantum interference device (SQUID) sensor that converts magnetic flux to voltage, and is the most sensitive sensor to detect magnetism. In this paper, analysis of myocardium current density distribution maps is proposed. Effec...