An aerobic succinate production system developed by Lin et al. (Metab Eng, in press) is capable of achieving the maximum theoretical succinate yield of 1.0 mol/mol glucose for aerobic conditions. It also exhibits high succinate productivity. This succinate production system is a mutant E. coli strain with five pathways inactivated: DeltasdhAB, Delta(ackA-pta), DeltapoxB, DeltaiclR, and Deltapts...

It is difficult to estimate the maximum in vivo aerobic ATP production rate of the intact heart independent of limitations imposed by blood flow, oxygen delivery, and maximum mechanical power. This value is critical for establishing the kinetic parameters that control oxidative phosphorylation, as well as for providing insights into the limits of myocardial performance. In this study, the maxim...

RATIONALE Low aerobic exercise capacity is a powerful predictor of premature morbidity and mortality for healthy adults as well as those with cardiovascular disease. For aged populations, poor performance on treadmill or extended walking tests indicates closer proximity to future health declines. Together, these findings suggest a fundamental connection between aerobic capacity and longevity. ...

Purpose: Allometry is a method to express the relationship between physiological and anatomical variables. It can be used to measure the vital capacity through mathematical equations. This study aimed at evaluating lung function indices to estimate the maximal aerobic power by respiratory gas analysis device and the allometric equation. Methods: This study was a descriptive and correlational r...

ABSTRACT Introduction: Maximum oxygen uptake is an effective indicator of the level human cardiopulmonary function and aerobic work capacity. Observing effects training formulating scientific plans are considerable value. Objective: To observe effect physical exercise on body's maximum arterial blood ketone body ratio. Methods: Before after 4 weeks exercise, uptake, lactic acid heart rate chang...

Introduction: One of the benefits provided by regular physical activities seems to be the improvement of cardiac autonomic nervous system modulation. However, the role of physical activity as a determinant factor of the heart rate variability (HRV) is not well-established. Therefore, the aim of this study was to verify whether there was a correlation between resting heart rate and maximum workl...

OBJECTIVE To confirm that electrical myostimulation is a good alternative to conventional aerobic training in patients with chronic heart failure and to compare the effects of both training programmes in patients with different exercise capacities. PATIENTS AND METHODS A total of 44 patients with stable chronic heart failure underwent 5 weeks of exercise training, with electrical myostimulati...

In a recent paper, Farmer (2000) offered a novel and stimulating hypothesis for the convergent evolution of endothermy in birds and mammals. She proposed that a high level of nonshivering thermogenesis by adults evolved because of the benefits it provided to their developing embryos. Initially, a higher standard metabolic rate (SMR), and consequently a higher body temperature, served only to in...

In recent years, breakpoints (Bp) of muscle oxygenation have been measured in local muscles using near infrared spectroscopy (NIRS) to assess (predict) systemic aerobic capacity indices [lactate threshold (LT), gas exchange threshold (GET) and maximal oxygen uptake (VO2peak)]. We investigated muscular differences in the assessment (predictive) ability of the Bp of muscle oxygenation for aerobic...

BACKGROUND Patients with fibromyalgia present a reduced capacity of upper and lower limb physical performance and affect their independence in performing everyday activities. OBJECTIVE The purpose of the present systematic review was to summarize evidence for the effectiveness and structure of exercise programs on functional aerobic capacity in patients with fibromyalgia syndrome. METHODS K...