Introduction: Profilin1 (PFN1) is a ubiquitously expressed protein known for its function as a regulator of actin polymerization and dynamics. A recent discovery linked mutant PFN1 to Amyotrophic Lateral Sclerosis (ALS), which is a fatal and progressive motor neuron disease. We have also demonstrated that Gly118Val mutation in PFN1 is a cause of ALS, and the formation of aggregates containing m...

We propose a new technique named Fuzzy Max–Min Composition to Study the Sanchez's approach for Medical Diagnosis [13] and with the notion IFS [15].

In this study, we investigated whether the previously established differences between fast- and slow-twitch single skeletal muscle fibers of the rat, in terms of myosin heavy chain (MHC) isoform composition and contractile function, are also detectable in excitation-contraction (E-C) coupling. We compared the contractile responsiveness of electrophoretically typed, mechanically skinned single f...

Abstract Background and Objectives Protein gluten content composition are important for the baking quality of wheat flours. Our aim was to provide a comprehensive characterization 82 flours analyze influence protein on rheological parameters. Findings composition, starch gelatinization behavior, as well (microfarinograph, aggregation, extensibility), parameters were determined. The correlation ...

This paper presents a fluid-particle interaction algorithm using the distributed Lagrange multiplier based fictitious domain method. The application of this method to the numerical investigation of motion and aggregation of red blood cells in two-dimensional microvessels is discussed. The cells are modelled as rigid biconcave-shaped neutrally buoyant particles. The aggregating force between two...

The frequency dependence of the ultrasonic backscattering coefficient (BSC) was studied to assess the level of red blood cell (RBC) aggregation. Three monoelement focused wideband transducers were used to insonify porcine blood sheared in a Couette flow from 9 to 30 MHz. A high shear rate was first applied to promote disaggregation. Different residual shear rates were then used to promote forma...

The feasibility of detecting red blood cell (RBC) aggregation with photoacoustics (PAs) was investigated theoretically and experimentally using human and porcine RBCs. The theoretical PA signals and spectra generated from such samples were examined for several hematocrit levels and aggregates sizes. The effect of a finite transducer bandwidth on the received PA signal was also examined. The sim...

As most robust combinatorial min-max and min-max regret problems with discrete uncertainty sets are NP-hard, research in approximation algorithm and approximability bounds has been a fruitful area of recent work. A simple and well-known approximation algorithm is the midpoint method, where one takes the average over all scenarios, and solves a problem of nominal type. Despite its simplicity, th...

In the literature, the solution set of a system of bipolar fuzzy relational equations with max-min composition can be characterized by a finite set of maximal and minimal solution pairs. However, some researches presented that determining the consistency of a system of bipolar fuzzy relational equations is NP-complete. Namely, the solution procedure for solving a system of bipolar fuzzy relatio...