in order to enhance in vitro dissolution and content uniformity of poorly soluble drug glimepiride by preparing solid dispersions using modified solvent fusion method, solid dispersions of drug were prepared by modified fusion solvent method using peg 6000 and pvp k25 (as carrier). eight batches (f1-f8) were prepared by factorial design (23) by taking three factors i.e. the concentration of: dr...

The concept of a relaxation spectrum is used to compute the absorption and dispersion of a linear anelastic solid. The Boltzmann aftereffect equation is solved for a solid having a linear relationship between stress and strain and their first time derivatives, the 'standard linear solid', and having a distribution of relaxation times. The distribution function is chosen to give a nearly constan...

The authors investigated the features of structural-phase state a composite based on stainless austenitic steel with addition 25% (vol.) aluminum bronze. was obtained by electron beam additive technology simultaneous feeding two wires. paper considers analysis and mechanical characteristics. contributions various mechanisms to hardening were evaluated. It established that multiphase structure i...

a simple and sensitive method has been developed for the preconcentration and determination of trace level of co(ii) using uv-vis spectrophotometry. β-cyclodextrin polymer modified with 1-(2-pyridylazo)-2-naphthol (pan) is used for the preconcentration of co(ii) from samples at ph 8.5. the polymer is synthesized and characterized using elemental analysis, ft-ir and sem analysis. the factors aff...

Glycerol derivatives of cutin and suberin monomers were synthesized by acid catalysis. Their dispersion in an aqueous solution was examined by phase contrast microscopy, neutron scattering, and solid state NMR. It is shown that the phase behavior strongly depends on the nature of the derivatives forming either lumps of aggregated membranes or well dispersed membranes.

A n experimental investigation of a solid–liquid dispersion pipe flow was conducted using a pulsed ultrasonic Doppler velocimeter. The solid phase was composed of buoyant particles dispersed in water. This particular two-phase flow was used to mimic the behaviour of ice–water flow. Four diagnostics were used to study the complex nature of the two-phase flow mixtures: mean velocity profiles, spa...

The present study aims to experiment the solid dispersion of poorly water soluble drug itraconazole as model drug by spray drying method with the use of PEG/HPMC polymer blends, the influence of polymer compatibility on the degree of molecular dispersion of itraconazole solid dispersions are prepared by ternary mixing and polymer blends are also evaluated for DSC, XRD and in vitro dissolution t...