Macrophage Activating Syndrome (MAS) is a life-threatening disease seen in autoimmune diseases including lupus erythematosus, rheumatoid arthritis, Still's disease, polyarteritis nodosa. It is characterized by fever, pancytopenia, liver failure, coagulopathy, and neurologic symptoms and high serum ferritin. A 27 yr. old female patient was admitted in shahid Mostafa Khomeini Hospital (Tehran-Ira...

OBJECTIVE To assess performance of the 2016 macrophage activation syndrome (MAS) classification criteria for patients with systemic juvenile idiopathic arthritis (JIA) who develop MAS while treated with biologic medications. METHODS A systematic literature review was performed to identify patients with MAS while being treated with interleukin (IL)-1 and IL-6 blocking agents. Clinical and labo...

Engineering multi-agent systems (MAS) is known to be a complex task. One of the reasons lays in the complexity to combine multiple concerns that a MAS has to address, such as system functionality, coordination, robustness, etc. A well-recognized approach to manage system complexity is the use of self-adaptation (SA). Self-adaptation extends a system with support to monitor and adapt itself to r...

We read with deep interest the paper by Ravelli et al, who developed new criteria for the classification of macrophage activation syndrome (MAS) in patients with systemic-onset juvenile idiopathic arthritis (So-JIA). The hemophagocytic lymphohistiocytosis (HLH) diagnostic guidelines have been successfully used in the management of primary HLH, but there have been several limitations to their us...

Multi-agent systems (MAS) are now being considered a promising architectural approach for designing collaborative information systems. In such a perspective, the concept of delegation has often been considered as a key concept for modeling cooperative behavior in MAS. However, despite considerable work on delegation mechanisms in MAS, few research efforts have aimed at truly defining a delegati...

This paper outlines a practical approach to the formal development of multi-agent systems (MAS). Rigorous design practices are needed if MAS are to be used for critical applications. Event-B is a formal method that can be used in the development of reactive systems. Decomposition is used as part of the approach to reduce the complexity of modelling MAS. The experience of modelling MAS Interacti...