Abstract Aim To assess the speed of resolution breast abscesses presenting to unit. There is significant variation in management between units at a national level. Whilst MAMMA study results are awaited, we wished understand our unit’s outcomes order improve patient journey. Method A single centre retrospective service evaluation acute abscesses. The project was approved on hospitals online QSI...

Tamoxifen is the standard adjuvant endocrine therapy for estrogen-receptor positive premenopausal breast cancer patients. However, tamoxifen resistance is frequently observed under therapy. A tamoxifen resistant cell line has been generated from the estrogen receptor positive mamma carcinoma cell line MCF-7 and was analyzed for putative differences in the aldehyde defence system and accumulatio...

AIM To investigate urban-rural differences in the distribution of risk factors for breast cancer. METHODS We analyzed the data from the first round of the "Mamma" population based-screening program conducted in Croatia between 2007 and 2009 and self-reported questionnaire results for 924 patients with histologically verified breast cancer. Reproductive and anthropometric characteristics, fami...

BACKGROUND Not all patients with locally advanced rectal cancer (LARC) respond equally to neo-adjuvant radiochemotherapy (RCT). Patients with highly apoptotic less advanced rectal cancers do not benefit from short-term radiotherapy. This study investigates whether this is also the case in the setting of RCT for LARC. PATIENTS AND METHODS Tissue microarrays were constructed of biopsy and resec...

DNA based transposon vectors offer a mechanism for non-viral gene delivery into mamma‐ lian and human cells. These vectors work via a cut-and-paste mechanim whereby transpo‐ son DNA containing a transgene(s) of interest is integrated into chromosomal DNA by a transposase enzyme. The first DNA based transposon system which worked efficienty in human cells was sleeping beauty. This was followed a...

HOSHIAT, H., TAKAHASHI, K., FURUHASHI, N., WADA, Y., UEHARA, S. and SUZUKI, M. Cytoplasmic Estrogen Receptors of Rat Mammary Glands during Pregnancy and Puerperium. Tohoku J. exp. Med., 1982, 136 (2), 195-202 The variation of cytoplasmic estrogen receptor in the mammary gland during pregnancy and puerperium was studied to determine the role of estrogens in the mechanism of lactation. Cytosol es...

(+/-)-Aeroplysinin-1, an optically active 1,2-dihydroarene-1,2-diol, was isolated from the marine sponges Verongia aerophoba (+-isomer) and Ianthella ardis (- -isomer). For the experiments presented we used the +-isomer from Verongia aerophoba. Here we describe the hitherto unknown biological and pharmacological property of this compound to display pronounced anticancer activity against L5178y ...

1. In the higher animals control of the functions of the body is dual, being partly neural and partly humoral. 2. When the control of any function is single and not dual, it is entirely neural. Exceptions to this statement appear to occur in connexion with the secretion of urine and milk, since these functions have not hitherto been shown to be under direct neural control. The mamma, and perhap...

The Her2/neu tyrosine kinase receptor is a member of the epidermal growth factor family. It plays an important role in tumour genesis of certain types of breast cancer and its overexpression correlates with distinct diagnostic and therapeutic decisions. Nevertheless, it is still under intense investigation to improve diagnostic outcome and therapy control. In this content, we applied spectral p...

OBJECTIVE Epicutaneous application of capsaicin causes a long-lasting analgesic effect by binding to the membrane transient receptor potential vanilloid 1 (TRPV1) on mechanoheat-sensitive C and Aδ fibres, changing axonal integrity and inhibiting neurogenic inflammatory processes. To date, no information is available regarding the cutaneous drug delivery of capsaicin following patch application....