BACKGROUND The most frequent cytogenetic alteration in gastrointestinal (GI) B cell lymphoma (BCL) is t(11;18)(q21;q21). GI B cell non-Hodgkin lymphomas lacking this translocation vary in their biology and clinical outcome. The t(11;18) negative subgroup shows increased numerical changes of chromosome 18, although its clinical relevance remains unknown. METHODS Thirty surgically resected prim...

Mucosa-associated lymphoid tissue (MALT) lymphoma usually originates from the stomach and presents with low 18F-fluorodeoxyglucose (FDG) avidity with average maximum standard uptake value of 3.6. Colorectal MALT lymphoma is a rare entity that contributes to 1.6% of all MALT lymphomas and < 0.2% of large intestinal malignancies. The case reported herein firstly revealed stage IIE MALT lymphoma w...

Thyroid lymphoproliferative disorder is known to be associated with Hashimoto thyroiditis. The major histological types of thyroid disorders are malignant lymphoma, such as diffuse large B cell extranodal marginal zone lymphoma mucosa-associated lymphoid tissue (MALT), and follicular lymphoma. All these lymphomas; however, T represent only a minority cases. Since rarely develops heterogeneous e...

The most frequent ocular adnexal tumors and simulating lesions are lymphoproliferative disorders (LPDs), including malignant lymphomas and orbital inflammation with lymphoid hyperplasia or infiltration. IgG4-related orbital inflammation (IgG4-ROI) often involves lacrimal glands and other orbital tissues and is an important differential diagnosis. The present study evaluated clinical aspects of ...

To investigate the role of BCL6 in the pathogenesis of gastric lymphoma, we analyzed the BCL6 promoter region for BCL6 translocations, somatic hypermutations, and deregulating mutations in 43 gastric lymphomas, including 4 extranodal marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissues (MALT lymphomas), 33 diffuse large B-cell lymphomas (DLBCLs), and 6 composite DLBCLs with resi...

The gastrointestinal tract is the most common location of extranodal lymphomas and the stomach in particular serves as an excellent model to illustrate many of the general issues concerning extranodal lymphomas. The stomach is the most frequent site of involvement of extranodal gastrointestinal lymphomas with small intestine second in frequency. Large intestinal and rectal lymphomas are less co...

ried out in a local hospital revealed expansion both within and outside the liver bile duct but found no stone or neoplasm. Then, she was referred to our hospital where physical examination revealed epigastric tenderness while the liver, spleen, and superficial lymph nodes were not palpable. The patient’s main laboratory data showed no abnormality except for a slight elevation of tumor markers ...

Indolent B-cell non-Hodgkin’s lymphomas (IBCNHL) represent a heterogenous group of chronic diseases [1]. Follicular lymphomas grades 1 and 2 (FL1/2) are by far the most common, accounting for approximately 20% of all NHL worldwide. Indolent IBC-NHL also include small lymphocytic lymphoma (SLL), which is the tissue counterpart of B-chronic lymphocytic leukemia (B-CLL); [2], lymphoplasmacytic lym...

A 44-year-old woman with a 12-year history of Sjögren's syndrome (SS) developed a low-grade mucosa-associated lymphoid tissue (MALT) lymphoma in the parotid gland. Two years later, she presented with generalized lymphadenopathy and hepatosplenomegaly and a follicular lymphoma was diagnosed. To investigate the relationship of the two histologically distinct lymphomas, we re-examined their histol...

The t(11;18)(q21;q21) translocation is a specific marker for Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, there are no reliable markers to predict tumor response to H pylori eradication in patients without t(11;18)(q21;q21). Nuclear expression of BCL10 and nuclear factor kappa B (NF-kappaB) was recently found to be close...