to investigate the effects of the two-pore-domain potassium (k2p) channel task-3 in a syngeneic murine model for malignant glioma. malignant or high-grade glioma (who grade iii and iv) are the most common and most aggressive primary brain tumors in adults. despite aggressive multimodal therapy, the outcome of patients with malignant glioma remains poor. however, recent phase i and ii trials hav...

Malignant insulinoma is a rare neuroendocrine tumor, located exclusively in the pancreas, characterized by severe hypoglycemia secondary to excessive insulin secretion. Somatostatin analogs (SSA) and everolimus have been added classic treatment with diazoxide last years. Peptide receptor radionuclide therapy (PRRT) has also recently tested few patients apparently satisfactory results. We presen...

SUMMARY Occurance of Malignant Fihrous Histiocytoma (MFH) of the spermatic cord as a primary source is so rare that since I 967 Just 12 of such cases have heen reported (4,8, 10). MFH is one of the pleomorphic soft tissue Malignant tumors which has been studied for first time by Ozzello and Co workers on 1963. The Tumor ong1nates from primary Mesenchymal cells which have both histocytic & fi...

adrenocortical carcinoma (acc) is a rare tumor and usually a fatal disease which can develop at any age in either sex. differential diagnosis between malignant and benign adrenal mass is not easy which leads to significant clinical challenge for optimal treatment. here we report a 22-year-old woman diagnosed with primary hyper aldostronism initially but disease relapsed during six months and ma...

sebaceous carcinoma is a relatively rare cutaneous tumor that is most commonly derived from the sebaceous glands located in periorbital area. the extraocular occurrence of this tumor is very rare. we report a case of an 85 years old woman who presented with a slowly enlarging mass on the right temporal region. histological examination of the lesion revealed a malignant sebaceous carcinoma occur...

Malignant mixed ovarian germ cell tumors are very rare malignant tumors, with a high degree of malignancy. They aggressive cancers affecting young adolescent girls. The commonest combination reported in literature is dysgerminoma and endodermal sinus tumors. Fertility sparing surgery followed by chemotherapy the treatment choice. objectives this case report advanced age presentation, unusual hi...

Introduction: Natural killer (NK) cells, of which CD56 is a specific marker, play an important role in host defense against tumors. Cancer stem cells, of which aldehyde dehydrogenase isoform 1 (ALDH1) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. We aimed to evaluate the expression of ALDH1 and CD56 in common salivary g...

colorectal cancer is the most common gastrointestinal cancer and the second leading cause of cancer deaths worldwide. the purpose of this study is to investigate the prevalence of epstein-barr virus in patients with colorectal carcinomas and polyps in comparison with healthy people. in this analytical  case-control study, 15 patients with colorectal cancer and 20 patients with colorectal polyp ...

Lymphoepithelial carcinoma is an extremely rare malignant tumor, especially those localized at the head and neck region. The histological prototype of lymphoepithelial undifferentiated nasopharyngeal carcinoma. Herein, we report a case tumor in left submandibular gland 20-year-old male. mass was surgically excised with gland, specimen pathologically confirmed to be