Flow-induced dilation of gracilis muscle arterioles was examined in both genders of control rats and rats chronically treated with N(omega)-nitro-L-arginine methyl ester (L-NAME). After L-NAME treatment (4 wk), systolic blood pressure was significantly increased compared with control, whereas the plasma concentration of nitrate/nitrite was significantly reduced. Isolated and pressurized arterio...

In resistance arteries, a chronic increase in blood flow induces hypertrophic outward remodeling. This flow-mediated remodeling (FMR) is absent in male rats aged 10 mo and more. As FMR depends on estrogens in 3-mo-old female rats, we hypothesized that it might be preserved in 12-mo-old female rats. Blood flow was increased in vivo in mesenteric resistance arteries after ligation of the side art...

Nickel damages the male reproductive system. We investigated beneficial effects of silibinin which has metal-chelating and antioxidant properties over nickel toxicity. Both antioxidative in testes overall related to sperm motility, membrane acrosome integrity orally administered Silibinin were evaluated against harmful 30 day intraperitoneal sulfate (5 mg/kg/day) administration rats. Male rats ...

Objectives To observe changes in actin and dendritic spines the hippocampus after propofol anesthesia, to evaluate role of these subsequent learning impairment both young (3-month-old) aged (20-month-old) male rats. Methods The shuttle box test was used from 1, 3, 7, or 14 days anesthesia. Both F-actin content hippocampal CA1 region were observed using immunofluorescent staining western blot as...

Sepia ink, a black suspension of melanin granules, is multifunctional marine bioactive material. The present study aims to evaluate the ameliorative effect ink extract (IE) cuttlefish (Sepia officinalis) during high dosage administration FA in rats. Kidney injury induced by single oral dose (250 mg /kg). Eighteen male Wistar albino rats were control, group, and FA+ IE group (250mg/kg). showed s...

Acute cytotoxicity (lactate dehydrogenase release) of trichloroethylene (TRI), S-(1,2-dichlorovinyl)glutathione (DCVG), and S-(1,2-dichlorovinyl)-L-cysteine (DCVC) in freshly isolated renal cortical cells and hepatocytes from male and female rats was evaluated to test the hypothesis that the assay provides a valid indicator of sex- and tissue-dependent differences in sensitivity to TRI and its ...