for bacteria, etc., as he can himself carry out with the aid of stains and a good microscope, and how to take material for sending to a well equipped bacteriological laboratory for a more complete examination, ft includes instructions for the clinical examination ot the blood, both for estimating haemaglobin and corpuscles and the search for malarial parasites. The diagnosis of cholera and plag...

The lizard malarias are a taxonomically and ecologically diverse group of parasites that offer excellent models for research on the ecology of malaria in free-ranging non-human vertebrate hosts. Studies over the past decade show that plasmodia of lizards can play an important role in the ecology and behavior of their hosts. The behavior of malarial infections in lizards also reveals unsuspected...

Experiments on the primary structure of a histidine-rich polypeptide isolated from the malarial parasite Plasmodium lophurae indicate that the smaller quantities of amino acids other than histidine form an integral part of the polypeptide and do not arise from a protein contaminating a histidine homopolymer. In culture, the parasites incorporate over 50% of exogenously supplied histidine into t...

Laveran ( I ) has consistently claimed f rom the beginning that the parasites were extracellular and that they attached themselves to the surface of the red corpuscles, adhering to them " b y pressing on them." Richard (2) thought at one time that the parasites were within the substance of the red corpuscle; but later (3) he returned to Laveran 's opinion that they were attached to the surface....

Sepoy, S. S., was admitted to the Indian MilitaryHospital, Alipore, on 19th March, 1932, complaining of severe headache, pain all over the body, and fever which started without shivering. Examination.?A well-nourished man, temperature? 103?F.; pulse?100 per minute, regular, soft, markedly dicrotic; abdomen soft, some tenderness in the right iliac fossa, superficial abdominal reflexes present; l...

Endoperoxide antimalarials based on the ancient Chinese drug Qinghaosu (artemisinin) are currently our major hope in the fight against drug-resistant malaria. Rational drug design based on artemisinin and its analogues is slow as the mechanism of action of these antimalarials is not clear. Here we report that these drugs, at least in part, exert their effect by interfering with the plasmodial h...

Malaria infects over 200 million individuals and kills 2 million young children every year. Understanding the biology of malarial parasites will be facilitated by DNA microarray technology, which can track global changes in gene expression under different physiological conditions. However, genomes of Plasmodium sp. (and many other important pathogenic organisms) remain to be fully sequenced so,...

life-history models predict an evolutionary trade-off in the allocation of resources to current versus future reproduction. This corresponds, at the physiological level, to a trade-off in the allocation of resources to current reproduction or to the immune system, which will enhance survival and therefore future reproduction. For clutch size, life-history models predict a positive correlation b...

In recent years it has become increasingly difficult to purchase ingredients for the preparation of various modifications of Romanowsky stains, such as Giemsa, Leishman and Wright's, at a reasonable cost; if indeed they can be obtained at all. During the past year, work has been in progress in the laboratories of the Malaria Institute of India with the object of producing a stain in which readi...