Structural and functional abnormalities have been extensively reported in major depressive disorder, but possible changes in cortical folding have not yet been explored in this disorder. This study investigated this issue in major depressive disorder using the local gyrification index. High-resolution magnetic resonance imaging was performed in 18 patients with first-episode major depressive di...

OBJECTIVE The purpose of this study was to examine the effects of specific personality disorder comorbidity on the course of major depressive disorder in a nationally representative sample. METHOD Data were drawn from 1,996 participants in a national survey. Participants who met criteria for major depressive disorder at baseline in face-to-face interviews (in 2001-2002) were reinterviewed 3 y...

BACKGROUND Over the past decade, studies of the effectiveness of pharmacological treatment for depression have often been based on research designs intended to measure efficacy, and for this reason the results are of limited generalizability. Research is needed comparing the clinical and economic outcomes of antidepressants in day-to-day clinical practice. METHODS A six-month randomised prosp...

Depressive symptoms are highly prevalent and clinically relevant in schizophrenia spectrum disorder (SSD) patients. So far, little is known about to what extent the depressive symptom profile SSD comparable that seen major (MDD). Data were derived from Genetic Risk Outcome of Psychosis study (GROUP) Netherlands Study Depression Anxiety (NESDA). We examined differences severity profiles distribu...

objective: considering reports on the comorbidities of some psychiatric disorders with epilepsy and in view of some variability in results and lack of needed data in the iranian population, this study aimed at a further systematic evaluation of various major psychiatric disorders in epileptic patients and compared the results with a control group. method: in this study, to assess mood, anxiety,...

Purpose: To investigate the effectiveness of metacognitive therapy in patients with major depressive disorder. The population of this study included all patients admitted to the Army Hospital No. 520 diagnosed with major depressive disorder from which 30 individuals were selected by using random sampling into experimental and control groups (n = 15 experimental and n = 15 control). Mater...

Background Prostaglandin (PG) D2 is the most abundant prostaglandin in the mammalian brain. The physiological and pharmacological actions of PGD2 in the central nervous system seem to be associated with some of the symptoms exhibited by patients with major depressive disorder. Previous studies have found that PGD2 synthase was decreased in the cerebrospinal fluid of major depressive disorder pa...

we investigated the association between serum 25(oh) d levels and depressive symptoms in patients with major depressive disorder (mdd).eighty-five adults, 44 drug free patients with mdd and 41 apparently healthy controls, participated in the study. the hamilton depression rating scale was used to assess severity of major depression. mental health of the controls was assessed according to dsm-iv...

CONTEXT Converging lines of evidence implicate the glutamate and γ-aminobutyric acid neurotransmitter systems in the pathophysiology of major depressive disorder. Transcranial magnetic stimulation cortical excitability and inhibition paradigms have been used to assess cortical glutamatergic and γ-aminobutyric acid-mediated tone in adults with major depressive disorder, but not in children and a...