PURPOSE To characterize with magnetization transfer imaging the pathologic substrate of the nonspecific periventricular hyperintense white matter changes seen on T2-weighted images of elderly patients. METHODS Twenty-one elderly patients with periventricular hyperintense white matter on T2-weighted MR images and eleven control subjects were studied using MT technique. Magnetization transfer r...

INTRODUCTION Volumetric loss of some cerebral structures is noticed during morphometrical investigations, and it is one of the most frequent abnormalities in schizophrenic patients' brains. The new methods of MRI investigations show subtle changes in cerebral white matter, which are undetectable by standard MRI. The magnetic transfer imaging (MTI) may be used to estimate the structural integrit...

MR magnetization transfer ratio was measured in both hippocampi of three patients with temporal lobe epilepsy, and in two control subjects. The magnetization transfer ratio in each section was significantly lower on the affected side than on the contralateral side and in control subjects. Magnetization transfer ratio measurements are relatively fast and precise, this preliminary study shows tha...

OBJECTIVES To establish a normative database for magnetisation transfer ratio (MTR) measurements in the white matter of healthy adult brains. Such MTR values were evaluated for regional variation and evidence of differences associated with aging, sex, and handedness. METHODS Forty one healthy volunteers, ranging in age from 16 to 55 years, underwent axial brain magnetisation transfer (MT) ima...

BACKGROUND To utilize a rabbit model of plaque disruption to assess the accuracy of different magnetic resonance sequences [T1-weighted (T1W), T2-weighted (T2W), magnetization transfer (MT) and diffusion weighting (DW)] at 11.7 T for the ex vivo detection of size and composition of thrombus associated with disrupted plaques. METHODS Atherosclerosis was induced in the aorta of male New Zealand...

PURPOSE To determine whether magnetization transfer imaging can improve visibility of contrast enhancement of multiple sclerosis plaques. METHODS Fifty-nine enhancing and 63 nonenhancing lesions in 10 patients with multiple sclerosis were evaluated to calculate contrast-to-noise ratios on conventional T1-weighted and T1-weighted magnetization transfer images. The signal intensity of the lesio...

Age-related dysfunction in dopaminergic neuromodulation is assumed to contribute to age-associated memory impairment. However, to date there are no in vivo data on how structural parameters of the substantia nigra/ventral tegmental area (SN/VTA), the main origin of dopaminergic projections, relate to memory performance in healthy young and older adults. We investigated this relationship in a cr...

There is a need to develop clinical outcome measures for future treatment trials, particularly for pediatric studies and for studies of rare disorders for which such outcome metrics are neither currently well-defined nor validated. Patient-reported outcome measures should reflect outcomes that are meaningful to patient-perceived quality of life and sensitive to patient-identified change over ti...

BACKGROUND Recently, we characterized a Gamma Knife® radiation necrosis mouse model with various magnetic resonance imaging (MRI) protocols to identify biomarkers useful in differentiation from tumors. Though the irradiation was focal to one hemisphere, a contralateral injury was observed that appeared to be localized in the white matter only. Interestingly, this injury was identifiable in T2-w...