The macrocycle of the title compound, C(36)H(24)N(4)O(3)S·2CHCl(3), contains a rigid framework with the nitro-gen and oxygen heteroatoms pointing in towards the center of the macrocyclic cavity. The macrocycle is essentially planar (r.m.s. deviation = 0.027 Å) except for the thio-phene ring. The dihedral angle between the thio-phene ring plane and the mean plane of the central macrocyclic core ...

In this paper, cubic nickel oxide nanoparticles were successfully prepared by solid-state thermal decomposition of nickel(II) macrocyclic Schiff-base complex at 450°C for 3 h without employing toxic solvent or surfactant and complicated equipment. nickel(II) macrocyclic Schiff-base complex was synthesized by the reaction of 1,2-bis(2-formyl-3-methoxyphenyl)propane, NiCl2•6H2O and 1,3-phenylened...

In this paper, cubic nickel oxide nanoparticles were successfully prepared by solid-state thermal decomposition of nickel(II) macrocyclic Schiff-base complex at 450°C for 3 h without employing toxic solvent or surfactant and complicated equipment. nickel(II) macrocyclic Schiff-base complex was synthesized by the reaction of 1,2-bis(2-formyl-3-methoxyphenyl)propane, NiCl2•6H2O and 1,3-phenylened...

Macrocyclic peptides can interfere with challenging biomolecular targets including protein-protein interactions. Whereas there are various approaches that facilitate the identification of peptide-derived ligands, their evolution into higher affinity binders remains a major hurdle. We report a virtual screen based on molecular docking that allows the affinity maturation of macrocyclic peptides t...

macrocyclic heterobinuclear zn(ii)–cu(ii) complexes with phenol based dicompartmental ligands possessing contiguous hexa- and penta-coordination sites were prepared by a stepwise procedure. the ligands include similar n4o2 and dissimilar n(imine)3o2 and n(amine)3o2 coordination sites sharing two phenolic oxygen atoms. the six-coordination site comprises two pyridyl pendant arms on the amine nit...

This research explores the first design and synthesis of macrocyclic peptide aldehydes as potent inhibitors of the 20S proteasome. Two novel macrocyclic peptide aldehydes based on the ring-size of the macrocyclic natural product TMC-95 were prepared and evaluated as inhibitors of the 20S proteasome. Both compounds inhibited in the low nanomolar range and proved to be selective for the proteasom...

A series of 18-membered macrocyclic complexes of metal Ni(II) of the type [M(H2Cy )] have been synthesized and characterized on the basis of spectral, magnetic and conductivity studies. The macrocyclic ligands H 4 Cy1-4 (Fig. 1) are tetrabasic having four imido hydrogen but behave in a dibasic manner. Out of eight nitrogens, four imido and four imino, ligands utilize four imido nitrogens for sq...

As part of an ongoing study to construct a molecular Turing machine in which a polymer chain is encoded via allosteric information transfer between macrocyclic complexes, we describe the thermodynamic and kinetic characterization of a multicomponent self-assembled system based on a zinc porphyrin macrocyclic compound, a bidentate ligand (1,4-diazabicyclo[2.2.2]octane, DABCO), and a viologen-sub...

Anthelmintic resistance has been reported in most sheep producing countries. Prior to the mid 1990s, reports of anthelmintic resistance in Ireland were sparse and focused on benzimidazole, one of the three classes of anthelmintic available during this period. This evidence for efficacy issues on Irish farms combined with awareness that anthelmintic resistance was increasingly being reported in ...

Library Generation Analysis and Combinatorial Chemistry: dedicated to Bruce Merrifield 1 Bruce Merrifield Dynamic Combinatorial Assembly of Peptide-Rhenium Coordinates: Application to the Selection of hCyp-18 inhibitors from a Library of 12 × 16 Components 3 Dynamic Combinatorial Assembly of Peptide-Rhenium Coordinates: Coordination Chemistry for Generating New Analogs of hCyp-18 Ligands 5 Oxor...