A BODIPY-labeled macrocyclic heptaoxazole, L1BOD-7OTD, was developed as a fluorescent ligand for G-quadruplexes. The results of the study show that L1BOD-7OTD both selectively induces the formation of intramolecular G-quadruplexes from some G-quadruplex forming oligonucleotides (GFOs). In addition, the labelled macrocyclic heptaozaxole strongly binds to and stabilizes intramolecular G-quadruple...

Three novel complexes of Cu(II), Co(II) and Zn(II) using a macrocyclic ligand derived by the condensation of diethylphthalate and benzidine have been designed,synthesized and characterized by UV-Vis.,IR,Mass and Elemental analyses data in order to find out their antifungal activities. The stoichiometry of the complexes has been found to be 1: 1(Metal : Ligand). The analytical data indicate that...

Macrocyclic compounds represent a structural class with exceptional potential for biological activity; however, they have historically been underrepresented in screening collections and synthetic libraries. In this article we report the development of a highly step-efficient strategy for the diversity-oriented synthesis of complex macrocyclic architectures, using a modular approach based on the...

some new macrocyclic dibenzotrioxadiamides, dibenzotetraoxadiamide, dibenzopentaoxadiamide, dibenzothiatrioxadiamide, tribenzotrioxadiamides and tetrabenzohexaoxadiamide (14-21), (26) and (27) have been prepared. these compounds were obtained in the macrocyclization step by reacting the diamine (4) with appropriak dicaxboxylic acid dichlorides (5-13) and (24). the cyclization does not require h...

Abstract A unique family of chiral peraza N 6 ‐macrocyclic ligands, which are conformationally rigid and have a tunable saddle‐shaped cavity, is described. Utilizing their manganese(I) complexes, the first example earth‐abundant transition metal‐catalyzed asymmetric formal anti‐Markovnikov hydroamination allylic alcohols was realized, providing practical access to synthetically important γ‐amin...

A simple, one-step synthesis of multinuclear Lewis acids can be driven with high selectivity towards either macrocyclic or polymeric arrays by appropriate choice of backbone framework.

One-pot, multi-molecular macrocyclization allows the highly selective preparation of strained macrocyclic aromatic hexamers structurally stabilized by an inward-pointing continuous hydrogen-bonding network.

A facile and flexible approach for the preparation of macrocyclic molecules containing different carbohydrate moieties is presented, employing the reaction cascade: click-dimerization and ring-closing metathesis.

Addition of metal salts to a diiridium macrocyclic complex leads the spontaneous formation supramolecular particles that react preferentially with small substrates and can tolerate glutathione additives.