D-Tetrahydrocannabinol (D-THC) is the principal psychoactive ingredient in marijuana. We examined the effects of DTHC on glutamatergic synaptic transmission. Reducing the extracellular Mg concentration bathing rat hippocampal neurons in culture to 0.1 mM elicited a repetitive pattern of glutamatergic synaptic activity that produced intracellular Ca concentration spikes that were measured by ind...

In the early 1980s several labs independently discovered and characterized the glycoprotein that eventually became known as tenascin. Immunohistochemistry revealed tenascin in everyone’s favorite extracellular matrix: around motile cells, at hot spots of proliferation and at sites of branching morphogenesis, near inductive events, in cartilage, tendons and quite prominently in the developing ne...

Brown adipocytes cultured from newborn combined-lipase-deficient (cld/cld) mice and castanospermine (CST)-treated 3T3-L1 adipocytes synthesize lipoprotein lipase (LPL) which is inactive and retained in the endoplasmic reticulum (ER) [Masuno, Blanchette-Mackie, Chernick and Scow (1990) J.Biol. Chem. 265, 1628-1638; Masuno, Blanchette-Mackie, Schultz, Spaeth, Scow and Okuda (1992) J. Lipid Res.33...

Protein synthesis is very active in cardiac muscle, and the isolated perfused rat heart has been shown to be sensitive to hormone administration (Morgan et al., 1971; Mowbray er al., 1975). We describe here a preparation of purified ribosomes in improved yield and in which the effects of insulin pretreatment have been preserved. Preparations of Flyribosomes from muscle generally involve attempt...

Interest in melanocytic nevi (moles) stems from their clinical, histologic, and epidemiologic association with melanoma. Few studies of nevi have been longitudinal (1,2), and all, apart from our own (3), have involved subjects 3 years old or older. Hence, little is known about the age at which nevi begin to develop. We compared rates of development of nevi from birth to 3 years of age in two co...

The Geometry of Interaction (GoI) framework, introduced by Girard, provides semantics of linear logic proofs originally, and of functional programs as well via the Curry-Howard correspondence. Notably the obtained program semantics—what we shall call “GoI semantics”—captures dynamics of program execution while the semantics is denotational and compositional. This feature of GoI semantics leads ...

Algorithms for classification and taxonomy based on criteria as information entropy and its production are proposed. Some local anaesthetics, currently in use, are classified using five characteristic chemical properties of different portions of their molecules. Many classification algorithms are based on information entropy. When applying the procedures to sets of moderate size, an excessive n...

of the traditional smooth inversion this information is provided as [2J The two-dimensional (2-D) magnetotelluric inverse problem an assumption that the solution, the geoelectrical model in the MT has been addressed by several authors. The most well-known case, should be represented by smooth functions. At the same time, approaches are the search for a smooth model [de Groot-Hedlin in some geol...

In the past decade there has been considerable discussion about the policy of the early selective screening of children at high risk of suffering from handicapping conditions which are not apparent at birth. This policy was advocated by Lindon (1961) and Sheridan (1962), who felt that universal screening of all infants was not practicable at that time. Sheridan in particular considered that it ...

Faculty of Law and Faculty of Medicine and Dentistry, and Research Director, Health Law Institute, Un ivers ity of Alberta. Colin Feasby, LL.M ., J.S .D. Candid ate, C olum bia U niver sity. W e would like to thank Tracy Bailey and N ina Haw kins for their valuable assistance and the Alberta Heritage Foun dation for M edical Research fo r their continued su pport. See, for example, Canada, Natu...