In the pituitary gland, activating mutations of the GNAS1 (Gsalpha) gene at Gln227 have been identified in adrenocorticotrophin secreting, growth hormone secreting, and prolactin secreting adenomas. To date, mutations at the codon encoding R201, typically underlying the McCune-Albright syndrome and isolated fibrous dysplasia of bone, have been demonstrated only in growth hormone secreting pitui...

Introduction Fibrous dysplasia is a non-hereditary disease of childhood, of unknown etiology, in which fibrous tissue replaces normal bone. There is a wide spectrum of involvement, from asymptomatic isolated bonelesions to severe debilitation and the rare Albright’s syndrome of osteitis fibrosa disseminata, hyperpigmented skin lesions and endocrine dysfunction (Albright et al. 1937). The follow...