background: systemic lupus erythematosus (sle) is a chronic autoimmune disease which is characterized by b-cell abnormality and auto-antibody generation. since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with sle. objective: to investigate humoral immunity and specific-antibody formation in response to a...

the district of miyān kūh in the ardal town,chahār mahāl bakhtiari province, because of its high mountains, deep valleys and the fields among small mounts, being placed in the path of the was dering tribes has been the focus of the attention. the rigion has two different viewpoint. one part featuring the mounts chēhēl cheshme and gereh with the altitude of more than 3500 m., has cold winter and...

objective (s): from a genetic point of view, epilepsy is a polygenic multifactorial syndrome. the scn1a and b genes belong to a family of genes that provide instructions for making sodium channels. understanding the relevance of scn1a and scn1b gene polymorphisms to plasma concentration of carbamazepine (cbz) and its active metabolite carbamazepine 10, 11 epoxide (cbze), may shed more light on ...

myeloperoxidase (mpo) and paraoxonase-1 (pon1) are inflammatory and anti-inflammatory enzymes, respectively that have been involved in the pathogenesis of coronary artery disease (cad). in this study we sought to evaluate the relations of mpo and pon1 with high density lipoprotein (hdl) mean size in patients with acute coronary syndrome (acs). collectively, 50 control subjects and 50 patients w...

objective(s) two new adjuvants from natural animal lipids (g2) and bacterial polysaccharide extracts (pc) were previously prepared by our group and showed a reduction in tracheal responsiveness. the aim of this study was to evaluate the preventive effect of recently introduced natural products (g2 and pc) on the development of asthma. materials and methods asthma was induced using a standard me...

background: it has been reported that vitamin d has broad anti-inflammatory and immunomodulatory effects. objective: to evaluate the effects of vitamin d on the expression of il-27 and il-33 in a model of experimental autoimmune encephalomyelitis (eae). methods: eae was induced in c57bl/6 mice by immunization with myelin oligodendroglial glycoprotein mixed with complete freund's adjuvant. ...

the interaction between immune cells and endothelial lining of blood vessels is vital in many processes such as inflammatory and immune responses as well as cancer cell metastasis. the expression level of vcam-1 is regulated by many factors including the promoter activity that is possibly affected by the single nucleotide polymorphisms (snps) present in the promoter. there are previous reports ...

objective(s) 7-prenyloxycoumarins including 7-isopentenyloxycoumarin, auraptene and umbelliprenin, and herniarin have been widely recognized as bioactive coumarins. this paper presents the ways to synthesis these compounds. materials and methods 7-prenyloxycoumarins were synthesized by reaction between 7-hydroxycoumarin (' m) and relevant prenyl bromides (1.5 m) in acetone at room temperat...

to design the equipment and facilities for preservation, storage and processing of pomegranate, it is necessary to know the specific heat and thermal conductivity of the fruit components. the specific heat of exocarp, mesocarp and of seeds of pomegranate were assessed at three moisture content levels (30, 50 and 76% for seed and mesocarp; 15, 35 and 52% for exocarp) and at four temperature leve...

this study was conducted to investigate the effects of different temperatures on seed germination of plantago ovata and also to evaluate cardinal temperatures. various constant temperatures (5, 10, 15, 20, 25, 30 and 35ºc) were conducted in a completely randomized design with four replications. the germinated seeds were counted every day and the rate of germination percentage, cumulative germin...