Ro 63-0563 [4-amino-N-(2,6 bis-methylamino-pyridin-4-yl)-benzene sulfonamide] is a high affinity 5-hydroxytryptamine6 (HT6) receptor antagonist with more than 100-fold selectivity for the 5-HT6 receptor compared with 69 other receptors and binding sites. The present study describes the properties of [3H]Ro 63-0563, the first selective 5-HT6 receptor radioligand. Specific binding of [3H]Ro 63-05...

STRATEGIES FOR THE SYNTHESIS OF LYSERGIC ACID. (+)-Lysergic acid [(+)-1] is a precursor of several substances with well-established pharmacological properties, including some drugs approved and commercialized around the world. Thus, importance (+)-1 as synthetic target becomes undoubted various strategies for synthesis its tetracyclic core have been reported in literature. Therefore, this revie...

Drug abuse robs individuals of their jobs, their families, and their free will as they succumb to addiction; but may cost even more: a life of disability or even life lost due to stroke. Many illicit drugs have been linked to major cardiovascular events and other comorbidities, including cocaine, amphetamines, ecstasy, heroin, phencyclidine, lysergic acid diethylamide, and marijuana. This revie...

Dipropyltryptamine (DPT) is a hallucinogenic drug that has a shorter duration of action than lysergic acid diethylamide (LSD) and a relatively abrupt termination of activity. This study is an evaluation of the effectiveness of DPT compared to a placebo on a number of dimensions commonly regarded as significant in psychotherapy. Eighteen alcoholic patients received a total of 72 DPT and 64 place...

Lysergic acid diethylamide (LSD) is a semisynthetic compound with strong psychoactive properties. Chemically related to serotonin, LSD was initially hypothesized to produce a psychosislike state. Later, LSD was reported to have benefits in the treatment of addictions. However, widespread indiscriminate use and reports of adverse affects resulted in the classification of LSD as an illicit drug w...

One of the oldest models of schizophrenia is based on the effects of serotonergic hallucinogens such as mescaline, psilocybin, and (+)-lysergic acid diethylamide (LSD), which act through the serotonin 5-HT(2A) receptor. These compounds produce a 'model psychosis' in normal individuals that resembles at least some of the positive symptoms of schizophrenia. Based on these similarities, and becaus...

The usefulness of molecularly imprinted polymer assisted paper spray ionization mass spectrometry (MIP-PSI-MS) for the determination methamphetamine in urine has been demonstrated. MIP-PSI-MS is a method which MIP synthesized on surface paper, producing chemically selective with molecular recognition sites target analyte. analyte extracted by substrate, posteriorly used conventional PSI-MS anal...