نتایج جستجو برای: lymphoblastic

تعداد نتایج: 35386  

Journal: :Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2014
Kuan-Nien Chou Yu-chieh Lin Ming-Ying Liu Ping-Ying Chang

Temozolomide (TMZ), an alkylating agent, is widely used for treating high-grade gliomas. TMZ has been reported to cause secondary myelodysplastic syndrome and acute myeloid leukemia. However, TMZ-related acute lymphoblastic leukemia is rare. Here we describe a 54-year-old woman with glioblastoma multiforme, who developed precursor-B acute lymphoblastic leukemia with translocation (4;11)(q21;q23...

Journal: :Haematologica 2010
Sabina Chiaretti Monica Messina Simona Tavolaro Giuseppe Zardo Loredana Elia Antonella Vitale Alessandro Fatica Paolo Gorello Alfonso Piciocchi Gina Scappucci Irene Bozzoni Claudio Fozza Anna Candoni Anna Guarini Robin Foà

BACKGROUND Until recently, few molecular aberrations were recognized in acute lymphoblastic leukemia of T-cell origin; novel lesions have recently been identified and a certain degree of overlap between acute myeloid leukemia and T-cell acute lymphoblastic leukemia has been suggested. To identify novel T-cell acute lymphoblastic leukemia entities, gene expression profiling was performed and cli...

Journal: :Haematologica 2010
Thomas Burmeister Nicola Gökbuget Stefan Schwartz Lars Fischer Daniela Hubert Annette Sindram Dieter Hoelzer Eckhard Thiel

BACKGROUND The t(9;22) and t(4;11) chromosomal translocations, which generate the BCR-ABL and MLL-AF4 fusion genes, define high-risk subtypes of acute lymphoblastic leukemia in adults. However, the prognostic impact of other rarer fusion genes is less well established in adult acute lymphoblastic leukemia than in the childhood form. DESIGN AND METHODS In the context of the German Multicenter ...

2013
Rashmi Ranjan Das Smeeta Gajendra Sameer Bakshi Rachna Seth Rajive Kumar

We report two cases that presented with unexplained acute renal failure and hyperuricemia and were subsequently diagnosed with T-cell acute lymphoblastic leukemia. The patients improved with conservative therapy without the need for dialysis. Case 1 is the youngest case of acute lymphoblastic leukemia with spontaneous tumor lysis syndrome reported to date, and Case 2 presented with spontaneous ...

2017
Vahid Tavakoli Sundee Naing

REFERENCES 1. Young JL Jr, Miller RW. Incidence of malignant tumors in U. S. children. J Pediatr 1975;86:254-8. 2. Pui CH, Relling MV, Downing JR. Acute lymphoblastic leukemia. N Engl J Med 2004;350:1535-48. 3. Jonsson OG, Sartain P, Ducore JM, Buchanan GR. Bone pain as an initial symptom of childhood acute lymphoblastic leukemia: association with nearly normal hematologic indexes. J Pediatr 19...

Journal: :Journal of pediatrics & child care 2022

Introduction: L-asparaginase and corticosteroids are widely used in the chemotherapy of acute lymphoblastic leukemia (ALL). This combination is known to cause several adverse effects one which hypertriglyceridemia. Although condition asymptomatic reversible it can lead serious complications.

Journal: :Journal of the National Cancer Institute 2008
Dianne Pulte Adam Gondos Hermann Brenner

BACKGROUND Advances in the treatment of childhood hematologic malignancies have led to improvements in survival for several of these conditions during the past few decades, but most population-based survival data available to date refer only to patients diagnosed up to the mid-1990s. METHODS We used period analysis to assess trends in 5- and 10-year survival in US patients younger than 15 yea...

Journal: :Haematologica 2011
Philip Saunders Adam Cisterne Jocelyn Weiss Kenneth F Bradstock Linda J Bendall

BACKGROUND Despite incremental improvements in outcomes for patients with acute lymphoblastic leukemia, significant numbers of patients still die from this disease. Mammalian target of rapamycin inhibitors have shown potential in vitro and in vivo as therapeutic agents against a range of tumors including acute lymphoblastic leukemia. DESIGN AND METHODS Flow cytometry was used to evaluate drug...

Journal: :Haematologica 2008
Paola Ballerini Judith Landman-Parker Jean Michel Cayuela Vahid Asnafi Myriam Labopin Virginie Gandemer Yves Perel Gérard Michel Thierry Leblanc Claudine Schmitt Sylvie Fasola Anne Hagemejier François Sigaux Marie Françoise Auclerc Luc Douay Guy Leverger André Baruchel

BACKGROUND The prognostic value of the ectopic activation of TLX3 gene expression, a major oncogenetic event associated with pediatric T-cell acute lymphoblastic leukemia, is controversial. Likewise, the frequency and the prognostic significance in pediatric T-cell acute lymphoblastic leukemia of the newly characterized NUP214-ABL1 fusion transcript is not yet clear. DESIGN AND METHODS Two hu...

Journal: :Haematologica 2008
Atsushi Manabe Akira Ohara Daisuke Hasegawa Katsuyoshi Koh Tomohiro Saito Nobutaka Kiyokawa Akira Kikuchi Hiroyuki Takahashi Koichiro Ikuta Yasuhide Hayashi Ryoji Hanada Masahiro Tsuchida

BACKGROUND Treatment response has become one of the most important prognostic factors in childhood acute lymphoblastic leukemia. We evaluated the significance of the complete clearance of peripheral leukemic blasts on survival in children with acute lymphoblastic leukemia. DESIGN AND METHODS Seven hundred and fifty-four children diagnosed with acute lymphoblastic leukemia, consecutively enrol...

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