We present the case of a 55-year-old white male with biopsy-proven left inguinal lymph node metastasis from differentiated papillary thyroid cancer. Inguinal node metastasis from papillary thyroid cancer is an extremely rare finding. The case demonstrates that papillary thyroid cancer is capable of metastasis presumably through the lymphatic system to unexpected locations.

Lymphatic vessels are the major routes of human esophageal squamous cell carcinoma (ESCC) metastasis. Tumor cells secrete pro-lymphangiogenic factors to induce new lymphatic vessels, promoting lymph node metastasis. In this study, we show that RAS association domain family 8 (RASSF8) expression in ESCC clinical samples was inversely correlated with lymph node metastasis and patients survival. T...

Neoplastic diseases account for approximately 13% of the annual incidence of pleural effusions, and 75% of these effusions are secondary to malignancies of the lungs and breast or lymphoma. The most common pathogenic mechanisms that produce malignant pleural effusions (MPE) are (1) pleural metastasis resulting in increased membrane permeability beyond the capacity of lymphatic drainage, (2) met...

Due to the fact that it reliably results in positive outcomes, lymph node flap transfer is becoming an increasingly popular surgical procedure for the prevention and treatment of lymphedema. This technique has been shown to stimulate lymphoangiogenesis and restore lymphatic function, as well as decreasing infection rates, minimizing pain, and preventing the recurrence of lymphedema. In this art...

No growth factors specific for the lymphatic vascular system have yet been described. Vascular endothelial growth factor (VEGF) regulates vascular permeability and angiogenesis, but does not promote lymphangiogenesis. Overexpression of VEGF-C, a ligand of the VEGF receptors VEGFR-3 and VEGFR-2, in the skin of transgenic mice resulted in lymphatic, but not vascular, endothelial proliferation and...

the primary carcinoma may secondarily invade bone tissue through direct extensions, blood circulation or lymphatic transportation particulary when it is arising from breast, prostate, kidney, thyroid and lung. metastatics tumors of bone are more common than primary tumor of bone. the most common tumor, which metastasizes into bone, is the breast adenocarcinoma. some metastatic tumors of bone in...

The lymphatic vascular system is a conduit for interstitial fluid extravasated from blood vessels and also plays important roles in maintaining immune responses, lipid uptake, and tissue homeostasis. In recent years, much attention has been given to lymphangiogenesis, a formation of new lymphatic vessels, because lymphangiogenesis has been shown to be involved in lymph node metastasis of tumors.1

OBJECTIVE This study aimed to investigate the effect of Sox3 expression on biological behaviors of esophageal squamous cell carcinoma (ESCC) and explore its possible mechanism. METHODS ESCC cell lines that highly expressed Sox3 were selected and transfected with lentivirus carrying sox3 siRNA to establish ESCC cell lines which expressed Sox3 of different levels. Using in vitro experiments inc...