The gene(s) encoded within major histocompatibility complex (MHC) act as one of the major genetic elements contributing to the susceptibility of murine systemic lupus erythematosus (SLE). We have recently demonstrated that lupus susceptibility is more closely linked to the I-E- H-2(b) haplotype than to the I-E+ H-2(d) haplotype in lupus-prone BXSB and (NZB x BXSB)F1 hybrid mice. To investigate ...

a rare case of tuberculosis of the glans penis is described in a 60 year old lranian individual

nephritis remains an important problem in patients with systemic lupus erythematosus (sle). we conducted retrospective study to evaluate the efficiency of intravenous pulse cyclophosphamide in lupus nephritis: from 1983 to 1993, we reviewed 133 patients with biopsy proven lupus nephritis, 47 of them excluded because of short period of follow-up or defective laboratory data. eighty six patients ...

Lupus is a complex heterogeneous disease characterised by autoantibody production and immune complex deposition followed by damage to target tissues. Animal models of human diseases are an invaluable tool for defining pathogenic mechanisms and testing of novel therapeutic agents. There are perhaps more applicable murine models of lupus than any other human disease. There are spontaneous models ...

Renal involvement occurs in 50-75% of children with childhood-onset systemic lupus erythematosus (cSLE). Proliferative lupus nephritis (LN) represents the most common pattern of renal involvement in cSLE. Despite aggressive treatment, progression to end stage renal disease can occur in up to 5-10% of children. Over the last 2 decades, tremendous advancements have been made in the treatment of p...

References 1. Levine SR, Welch KMA: Cerebrovascular ischemia associated with lupus anticoagulant. Stroke 1987; 18:257-263 2. Levine SR, Welch KMA: The spectrum of neurological disease associated with antiphospholipid antibodies: Lupus anticoagulants and anticardiolipin antibodies. Arch Neurol 1987;44: 876-883 3. Levine SR, Welch KMA: Antiphospholipid antibodies. Ann Neurol 1989;26:386-389 4. Ya...

Though pleuritis and pleural effusion are common in lupus patients they are distinctly rare as the initial manifestation of lupus. Diagnosis of lupus pleuritis is also a difficult task and often costly and lengthy immunological panels are employed to diagnose it. We report one case of systemic lupus erythematosus (SLE) presenting with lupus pleuritis as the first manifestation. We propose that ...

OBJECTIVE The pulmonary vascular targeted treatment for systemic lupus erythematosus-associated pulmonary arterial hypertension is similar to other connective tissue disease-associated pulmonary arterial hypertension. In addition, there also appears to be a role for immunosuppression in the overall management. However, the optimal immunosuppressive regimen and what patients will respond to trea...

this paper presents a 54-year-old female with lupus whom severe anaemia due to pure red cell aplasia (prca) was the first manifestation. there was seven years interval between prca onset and diagnosis of lupus. thymectomy due to thymoma had been carried out six years before but anaemia sustained. hypothyroidism and hypoparathyroidism were other associated diseases. severe anaemia and the need f...

Neonatal lupus erythematosus is an infrequent disease seen in newborns. It is caused by transplacental maternal autoantibody passage. Cutaneous involvement and congenital heart block (CHB) are the most common affections, although it may involve multiple organs such as the liver, lungs, blood, nervous or digestive systems. This article present a review of the four cases diagnosed in the past fiv...