Obesity impairs peri-operative lung function. To evaluate the impact of pressure support ventilation vs pressure controlled ventilation in moderately obese adults upon early postoperative lung function, we randomly assigned 68 moderately obese patients (body mass index 25-35 kg x m(-2)) undergoing minor surgery to receive intra-operative ventilation either with pressure support or pressure cont...

INTRODUCTION Lung fibrosis, reduced lung compliance, and severe hypoxemia found in patients with acute lung injury often result in a need for the support of mechanical ventilation. High-tidal-volume mechanical ventilation can increase lung damage and fibrogeneic activity but the mechanisms regulating the interaction between high tidal volume and lung fibrosis are unclear. We hypothesized that h...

Key points † Mechanical ventilation can have adverse effects on pulmonary function by several distinct mechanisms. † Patients undergoing one-lung ventilation or cardiopulmonary bypass are at increased risk of developing acute lung injury (ALI). † Protective ventilatory strategies may prevent or reduce ALI. † There is a lack of randomized controlled trials to guide optimal intra-operative ventil...

Pulmonary and cutaneous oxygen uptake (MO2) and lung ventilation were measured in frogs floating in water with access to air in respirometers, with and without ventilation of the skin provided by stirring. The frogs were exposed to hypoxia in both water and air, and were variably active. In inactive frogs floating in unstirred respirometers at 25 degrees C, 23% of total MO2 is through the skin....

Modern techniques to isolate the lungs, coupled with accurate continuous non-invasive monitoring, have made single-lung ventilation safe and easy to perform. Most patients maintain an adequate arterial oxygen tension during single-lung ventilation. In order to maximize oxygenation, efforts are directed towards optimizing perfusion and ventilation to the ventilated lung or increasing the oxygen ...

BACKGROUND Positive-pressure mechanical ventilation is essential in assisting patients with respiratory failure in the intensive care unit and facilitating oxygenation in the operating room. However, it was also recognized as a primary factor leading to hospital-acquired pulmonary dysfunction, in which pulmonary oxidative stress and lung inflammation had been known to play important roles. Cu/Z...