This research attempted to fabricate a gas-diverting valve using LTCC technology for the emerging field of meso-scale devices. A photolithographic process for patterning Low Temperature Co-Fired Ceramic (LTCC) tapes utilizing DuPont Green Tape tape coupled with DuPont Riston 9015, a dry photoresist, is described in detail. Based on the device design, calculations determining the theoretical r...

Introduction Within healthy cardiomyocytes, L-type calcium channel (LTCC) flux and cardiac contractility are linked through the process of calcium induced calcium release (CICR). Stimulation of cardiomyocytes with a β-adrenergic agonist acts to increase LTCC flux and consequently increases contractility. The effects of β-adrenergic stimulation are reversed by muscarinic stimulation. Although ab...

RATIONALE Disruption in subcellular targeting of Ca(2+) signaling complexes secondary to changes in cardiac myocyte structure may contribute to the pathophysiology of a variety of cardiac diseases, including heart failure (HF) and certain arrhythmias. OBJECTIVE To explore microdomain-targeted remodeling of ventricular L-type Ca(2+) channels (LTCCs) in HF. METHODS AND RESULTS Super-resolutio...

Title of dissertation: MODELING AND DESIGN OF MICROWAVE-MILLIMETERWAVE FILTERS AND MULTIPLEXERS Yunchi Zhang, Doctor of Philosophy, 2006 Dissertation directed by: Professor Kawthar A. Zaki Department of Electrical and Computer Engineering Modern communication systems require extraordinarily stringent speci…cations on microwave and millimeter-wave components. In mobile and integrated communicati...

With the ever-increasing demand on wireless spectrum by wide bandwidth applications, such as 3G mobile phones at RF frequencies, Multipoint Video Distribution System (MVDS) and Local Multipoint Distribution System (LMDS) in the millimeter-wave frequency range, there is a growing need to exploit higher and higher frequencies. So, mmwave field is becoming a rapidly emerging area of research. Keyw...

Microstrip-line-feeding waveguide aperture antenna is developed in the 70-90 GHz band. A double-layer LTCC substrate is attached to the waveguide aperture opened on the wall of the metal package. The bandwidth over 20 GHz is observed in the simulation and the experiment.

L-type Ca(2+) channels (LTCCs) are important for vascular smooth muscle cell (VSMC) contraction, as well as VSMC differentiation, as indicated by loss of LTCCs during VSMC dedifferentiation. However, it is not clear whether loss of LTCCs is a primary event underlying phenotypic modulation or whether loss of LTCCs has significance for vascular structure. We used small interference RNA (siRNA) tr...

Early afterdepolarizations (EADs) are voltage oscillations that occur during the repolarizing phase of the cardiac action potential and cause cardiac arrhythmias in a variety of clinical settings. EADs occur in the setting of reduced repolarization reserve and increased inward-over-outward currents, which intuitively explains the repolarization delay but does not mechanistically explain the tim...