The proinflammatory mediators leukotriene (LT) B(4) and LTC(4) must be transported out of cells before they can interact with LT receptors. Previously, we identified the multidrug resistance protein ABCC1 (MRP1) as an efflux pump for LTC(4). However, the molecular basis for the efflux of LTB(4) was unknown. Here, we demonstrate that human ABCC4 mediates the ATP-dependent efflux of LTB(4) in the...

BACKGROUND Inhalation of thermal water (TW) is traditionally used as part of the treatment of chronic obstructive pulmonary disease (COPD), but its benefit and mechanisms are controversial. We previously observed a reduced proportion of neutrophils in induced sputum after treatment with TW. OBJECTIVES The aim of this study was to determine whether inhalation of TW in COPD patients is associat...

BACKGROUND Prompt diagnosis and treatment of latent tuberculosis (TB) infection (LTBI) are needed to control TB. The aim of the study was to compare the performance of Quanti FERON-TB test (QFT) with conventional TST for the diagnosis of LTBI. METHODS In this analytical - comparison study, we enrolled 87 nurses working in teaching hospitals in Ahvaz. All study subjects were tested by TST. TST...

Activated blood platelets and macrophages metabolize prostaglandin H(2) into thromboxane A(2) and 12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid (12-HHT) in an equimolar ratio through the action of thromboxane synthase. Although it has been shown that 12-HHT is abundant in tissues and bodily fluids, this compound has long been viewed as a by-product lacking any specific function. We show that...

The present paper aims to develop an Artificial Neural Network (ANN) formula predict the lateral-torsional buckling (LTB) resistance of slender steel cellular beams. A finite element model is developed and validated through experimental tests followed by a parametric study. 768 models are employed train ANN formula. results compared with analytical as well equation predicted ANN. It was conclud...

background: rotaviruses (rv) are important viral diarrheal agents in calves. vaccination is an optimum measure to prevent bovine rotaviruses (brv) infection. however, little research on brv vp7 vaccine has been done and currently there is no brv vaccine. objective: to prepare a subunit vaccine of brv and investigate its efficacy. methods: total rna was extracted from ma104 cells infected with b...

We study fluid distributions endowed with hyperbolic symmetry, which share many common features Lemaitre–Tolman–Bondi (LTB) solutions (e.g., they are geodesic, shearing, and nonconformally flat, the energy density is inhomogeneous). As such, may be considered as symmetric versions of LTB, spherical symmetry replaced by symmetry. start considering pure dust models, afterwards, we extend our anal...

We obtain a scaling relation for spherically symmetric k-essence scalar fields $\phi(r,t)$ an inhomogeneous cosmology with the Lemaitre-Tolman- Bondi (LTB) metric. show that this reduces to known homogeneous when LTB metric Friedmann-Lemaitre-Robertson-Walker (FLRW) under certain identifications of functions. A lagrangian is set up and Euler-Lagrangian equations solved assuming $\phi(r,t)=\phi_...

Leukotrienes (LTs) are proinflammatory lipid mediators synthesized by the conversion of arachidonic acid (AA) to LTA(4) by the enzyme 5-lipoxygenase (5-LO) in the presence of 5-LO-activating protein (FLAP). 3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103) is a novel selective FLAP inhibitor in development fo...