Indonesia dianugerahi keanekaragaman hayati yang melimpah, salah satunya tanaman obat. Andong merah merupakan satu obat banyak digunakan masyarakat Indonesia. Penelitian eksperimental laboratorium ini bertujuan untuk menentukan aktivitas ekstrak daun andong terhapap kadar kolesterol, Low Density Lipoprotein (LDL), dan High (HDL) pada mencit hiperkolesterol. menggunakan 4 kelompok hewan uji, yai...

1. The livetin patterns of the two species Crocodylus porosus and Gallus domesticus were very different and it was difficult to find a correspondence. 2. In C. porosus the granules were a larger proportion of the total yolk but they contained very little lowdensity lipoprotein when compared with granules from hens' eggs. 3. The low-density lipoprotein was a lower proportion of the yolk of C. po...

In this study we measured the binding parameters of different apolipoprotein (apo) B-containing lipoproteins to the low density lipoprotein (LDL) receptor of HeLa cells. Our goal was to determine the respective roles of the different apolipoproteins of these particles, with particular emphasis on apos B, E, and C-III. Very low density lipoprotein from hypertriglyceridemic subjects (B to E molar...

In a community-based study of 301 subjects from 61 nuclear families, two distinct phenotypes (denoted A and B) were identified by nondenaturing gradient gel electrophoretic analysis of low density lipoprotein (LDL) subclasses. Phenotype A was characterized by predominance of large, buoyant LDL particles, and phenotype B consisted of a major peak of small, dense LDL particles. Previous analysis ...

BACKGROUND Levels of LDL (low-density lipoprotein) cholesterol in the population are declining, and increasing attention is being focused on residual lipid-related pathways of atherosclerotic cardiovascular disease risk beyond LDL cholesterol. Among individuals with low (<130 mg/dL) LDL cholesterol, we undertook detailed profiling of circulating atherogenic lipoproteins in relation to incident ...

OBJECTIVES Elevated blood cholesterol levels are a major risk factor for coronary artery disease, the leading cause of death worldwide. Probiotics have been investigated as potential cholesterol-lowering therapies, but no previous studies have assessed the effect of the probiotic yeast Saccharomyces boulardii on cholesterol levels in human volunteers. The objective of this study was to examine ...

Following entrapment in the arterial intima, low-density lipoprotein (LDL) can be modified by hydrolytic enzymes to yield a lipoprotein derivative that binds C-reactive protein, activates complement, and is rapidly taken up by monocytes/macrophages. Free fatty acids contained in enzymatically modified LDL (E-LDL) render the lipoprotein cytotoxic due to their capacity to trigger programmed cell ...

In view of the presence of some 190 mutations in the low density lipoprotein receptor (LDL-R) gene and a lack of simple detection methods, we have developed an improved assay system for detecting familial hypercholesterolemia (FH) using mitogen-induced proliferating lymphocytes. Freshly isolated mononuclear cells were cultured for 3 days in RPMI 1640 supplemented with 10% human lipoprotein-defi...

Background/aim: Juvenile obesity is associated with several metabolic abnormalities, one of them being atherogenic dyslipidemia. Suboptimal fetal growth is associated with obesity risk in childhood, but also with increased rate of metabolic diseases in later life. This study investigated associations of neonatal data (Apgar score, birth weight and birth length) with low-density lipoprotein and ...

A raised low-density lipoprotein (LDL) cholesterol (LDL-C) is one of the major risk factors for ath-erosclerotic cardiovascular disease (ASCVD) 1-3). Homozygous family hypercholesterolemia (HoFH) is a rare inherited disease characterized by markedly elevated levels of LDL-C, generally more than 500 mg/ dL when untreated, and a high risk of premature ASCVD 4). HoFH is caused by loss-of-function ...